Research
The Endocrinology and Metabolism Section is home to a rich tapestry of basic, clinical and translational research activities. Our research faculty are all successful investigators in their own right but also cooperate closely with other investigators in both basic and clinical departments to pursue interdisciplinary projects, a fact reflected by the 4 different interdepartmental research centers led by members of our Section (see below).
Details of each faculty member’s research program can be explored from links located within the faculty list for the Section.
Additional information about the endocrinology faculty and the other members of our research-training faculty can be located on the education page.
Research Centers
Diabetes Research Center (DRC)
The goal of the Yale DRC is to enhance the quality of research and training in diabetes and related metabolic and endocrine disorders at the University. The Center currently brings together a multidisciplinary group of nearly 100 member scientists, new investigators and research trainees from the Departments of Internal Medicine, Pediatrics, Immunobiology, Biology, Cell Biology, Molecular Biophysics and Biochemistry, Bioengineering, Genetics, Molecular, Cellular and Developmental Biology, Physiology, Pharmacology, Surgery, Orthopedics, Neurosurgery, Neurology, Psychiatry, Obstetrics and Gynecology, Diagnostic Radiology, Psychology, Pathology, Laboratory Medicine, and from the Schools of Public Health and Nursing and the Pierce Laboratory. The cornerstone of the Center is its 5 Research Cores (clinical metabolism core, molecular genetic mouse core, physiology core, cell biology core, and human translation core), which provide funded basic and clinical investigators with the opportunity to more efficiently utilize resources and expand the scope of their research programs.
Recent Publications
Jeong J, Choi J, Kim W, Dann P, Takyar F, Gefter JV, Friedman PA, Wysolmerski JJ.
J Biol Chem. 2019 Jan 18;294(3):887-901. doi: 10.1074/jbc.RA118.004143. Epub 2018 Nov 21. PMID: 30463939
NHERF1 Is Required for Localization of PMCA2 and Suppression of Early Involution in the Female Lactating Mammary Gland
Jeong J, Kim W, Hens J, Dann P, Schedin P, Friedman PA, Wysolmerski JJ.
Endocrinology. 2019 Aug 1;160(8):1797-1810. doi: 10.1210/en.2019-00230. PMID:31087002
Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression
Lotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier VT, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein ML, Wysolmerski J, Gori F, Baron R.
J Clin Invest. 2019 May 21;129:3058-3071. doi: 10.1172/JCI122936. PMID: 31112135
Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation
Rachel Zwick...Valerie Horsley
Nat Common.2018 Sep 4;9(1):3592. doi: 10.1038/s41467-018-05911-0.
Inhibition of ezrin causes PKCα-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells
Jaekwang Jeong...John J. Wysolmerski
J Biol Chem.2018 Nov 21. pii: jbc.RA118.004143. doi: 10.1074/jbc.RA118.004143. [Epub ahead of print]
Primary Hyperparathyroidism
Karl Insogna
N Engl J Med. 2018 Sep 13;379(11):1050-1059. doi: 10.1056/NEJMcp1714213.
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis
Karl L Insogna...Thomas O Carpenter on behalf of the AXLES 1 Investigators
Journal of Bone and Mineral Research, Vol. 33, No. 8, August 2018, pp 1383–1393