Yale Liver Center

The Yale Liver Center is one of 17 Digestive Diseases Research Core Centers (DDRCCs) supported by NIH/NIDDK. The Yale Liver Center has been funded continuously since 1984 and is one of only three that focus on the liver. The Yale Liver Center supports investigation of liver structure, function and disease. Research support is provided through the Center’s Four Core Facilities, as well as through Pilot Feasibility Projects that are offered annually.

The research base is focused on three broad areas of liver biology and pathobiology:

• Immunobiology and Inflammation
• Hepatic Metabolism
• Epithelial Biology and Pathobiology

Currently, 39 independent principal investigators are Members of the Center as well as 61 Associate Members, which involves 23 departments and sections at Yale.

The Liver Center also supports weekly research seminars (on Tuesday afternoons) and clinical lectures (on Friday afternoons), in conjunction with the Section of Digestive Diseases, Department of Internal Medicine.

The Research Base can be organized to reflect the fact that it is focused on three broad translational themes.

These include:

1. Immunobiology and inflammation
2. Hepatic metabolism
3. Epithelial biology and pathobiology.

The major areas of liver disease examined within these translational themes include autoimmune diseases, cholestasis, fibrosis/cirrhosis, genetic diseases, infections, liver cancer, and NASH/ASH. Many of our investigators have research interests that span multiple themes.