Karl L. Insogna MD

Professor of Medicine (Endocrinology); Director, Yale Bone Center

Departments & Organizations

Yale Medical Group

Cancer Center, Yale: Signal Transduction

Internal Medicine: Endocrinology: Bone Center; Fellowship Training | Diabetes Research Center | Yale Core Center for Musculoskeletal Disorders | National Gaucher Disease Treatment Center

Center for X-Linked Hypophosphatemia, Yale

Immunology and Immunotherapy

Research Interests

Role of dietary protein in skeletal metabolism; Factors that lead to skeletal disease in adult patients with X-linked hypophosphatemic rickets; Cellular mechanisms of PTH-induced bone resorption and bone anabolism; Effects of CSF1 in mature osteoclasts more...


  • M.D., University of Connecticut, 1976

Selected Publications

  • Hsieh E, Fraenkel L, Xia W, Hu YY, Han Y, Insogna K, Yin MT, Xie J, Zhu T, Li T. (2014) Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV. Osteoporosis Int., Sep 16. [Epub ahead of print]. PMID:25224293. PMC4334679.
  • Hsieh E, Fraenkel L, Bradley EH, Xia W, Insogna KL, Cui Q, Li K, Li T. (2014) Osteoporosis knowledge, self-efficacy, and health benefits among Chinese individuals with HIV. Arch Osteoporos, 9(1):201. Epub 2014 Dec 9. PMCID: 25487753. PMCID: PMC4269230 [Available 2015/12/9].
  • Insogna KL. The effect of proton pump-inhibiting drugs on mineral metabolism Am J Gastroenterol. 104 Suppl 2:S2-4. 2009. PMID: 19262542



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