Fred Gorelick, MD

Professor of Medicine (Digestive Diseases) and of Cell Biology; Deputy Director, Yale M.D., Ph.D. Program

Departments & Organizations

Cell Biology: Membrane Traffic

Internal Medicine: Digestive Diseases | Liver Center

LCME Academic Environment Subcommittee

Office of Student Research

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development: Human Disease; Membrane Traffic and Biogenesis; Receptors and Signal Transduction

Office of Cooperative Research


After completing medical school and internal medicine training at the University of Missouri, Dr. Gorelick trained at Yale in Gastroenterology. After his clinical training, he began basic science training with Dr. James Jamieson at Yale. During that period he described calcium-calmodulin dependent protein kinase II and subsequently worked with Dr. Paul Greengard (Rockefeller University) to examine the enzyme's mechanism of activation, a response critical to neuronal memory.

His later work has focused on the mechanisms of acute pancreatits and how digestive enzymes, such as trypsin, are activated within the pancreas during this disease. Dr. Gorelick sees patients with gastrointestinal diseases at the VAMC in West Haven, CT. He is also the Deputy Director for the Yale physician Scientist program and directs a year-long course for the group that links basic science to clinical disease. He laboratory at the VA studies the molecular mechanisms related to acute pancreatitis with a goal of developing tools that prevent or lessen disease.

Education & Training

MD University of Missouri (1973)
Visiting Scientist Rockefeller University
Post Doctoral Yale University
GI Fellow Yale University School of Medicine
Resident University of Missouri

Honors & Recognition

  • American Association of PhysiciansAAMC (2010)

  • William Go Life-time Achievement AwardAmerican Pancreatic Association (2008)

  • Bohmfalk Teaching Award in Basic ScienceYale University (2007)

  • ASCIAmer Soc Clin Investigation (1990)

  • Morton Grossman Research AwardAmerican Gastroenterological Association (1984)

Professional Service

  • NIH ZDKi GRB-2 Study Section NIH (2009 - 2009)

  • Deputy Director Yale MD, PhD Program Yale University (2009 - 2013)

  • NIH Study Section Chair (CIGP) National Institutes of Health (2004 - 2006)

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Contact Info

Fred Gorelick, MD
Mailing Address
Internal MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056

Curriculum Vitae

Research Image 1

Mechanisms of vacuolar ATPase activation in acute pancreatitis