Yale Antiphospholipid Syndrome Program

The Yale APS Program is an interdisciplinary collaboration across departments to facilitate the care, education and research around APS, an autoimmune disorder that can be associated with other rheumatic diseases including lupus.

Patient Care

APS is a systemic disorder that can affect any organ or tissue. APS affects women more frequently than men and may cause problems during pregnancy, clotting or blood disorders, or may occur with other autoimmune conditions such as lupus. We work with obstetricians, hematologist, rheumatologists and other specialists at Yale to provide comprehensive care of all aspects of APS. These specialists meet to discuss particularly challenging cases and collaborate to provide the best treatment.

Referrals to the clinic can be made through Epic or by faxing patient information and the new patient referral form to 203-785-7053.


Patient education is essential for any chronic condition but especially for APS patients because it is a rare disorder that has only been recognized recently

We also educate physician colleagues to raise awareness of APS and work collaboratively with them to provide coordinated care.

Specific patient resources are available at the following external websites:


Clinical research interests within the program include the role of antiphospholipid antibodies in neuropsychiatric manifestations and novel treatment approaches for APS and catastrophic APS. Basic research interests are centered around the pathogenesis of APS. A current study at Yale explores the role of commensal bacteria in APS (principal investigator Dr. Kriegel). Infectious triggers have long been associated with transient antiphospholipid antibodies and the current research aims to identify chronic triggers of APS within the gut microbiome (the collection of bacteria living in our gut). Interested patients who would like to be evaluated for eligibility of the ongoing microbiome study can find more information here and at ClinicalTrials.gov (Identifier NCT01787305).