Oligo Synthesis Resource

The Keck Oligonucleotide Synthesis facility provides high quality, timely DNA and RNA synthesis in individual tubes or plates. Synthesis is carried out on our Dr. Oligo 192 and Applied Biosystems 394 synthesizers. We routinely perform a wide variety of complex specialty syntheses, emphasizing quality and efficiency. Our services include:

• Modifications
• RNA & 2’-O-Methyl RNA
• Mixed Base/Doped Oligos
• Trityl ON Oligos
• UltraMild Synthesis
• Purification
• Protocols

^{DISCLAIMER: The Keck Oligo Synthesis Section warrants that its products shall conform to the description provided on the product’s accompanying literature or analytical data. ALL PRODUCT CLAIMS, REGARDLESS OF THEIR NATURE, MUST BE BROUGHT TO OUR ATTENTION WITHIN 60 DAYS OF DELIVERY. Due to the highly complex, customized and experimental nature of some modified oligos, we cannot guarantee the purity and yield of all modified products. Although we will do our best to ensure that the highest quality product is achieved, THE KECK OLIGO SECTION SHALL NOT IN ANY EVENT BE LIABLE FOR INCIDENTAL, CONSEQUENTIAL OR SPECIAL DAMAGES OF ANY KIND RESULTING FROM ANY USE OR FAILURE OF THE PRODUCTS NOR SHALL ITS LIABILITY IN ANY CASE EXCEED THE PURCHASE PRICE OF THE PRODUCT.}

Please see our Price Schedule for revised pricing effective 7/1/2022.

We are now offering a custom cloning service! Utilizing the BioXp™3200 System, dsDNA fragments from 350-1.8 kb can be cloned into the vector of your choice. Please inquire at oligos@yale.edu or click here for more details.

For all un-modified normal DNA oligos, a new 100 nmole synthesis scale has replaced our current 40 nmole scale at no additional cost… higher yields and free desalting for the same low price!

$0.20/base desalted <65 bases

$0.18/base desalted <65 bases in a 96-well plate

Normal, un-modified DNA oligos <100 bases synthesized at the 25 and 40 nmole scales are provided salt-free at no charge!

30%-60% discount on common specialty modifications such as 5'-FAM and 5-Me-dC!

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