Kevin C O'Connor, PhD

Associate Professor of Neurology

Departments & Organizations

Neurology: Multiple Sclerosis & Other Inflammatory Brain Disease | Nowak Lab | O'Connor Lab

Faculty Research


IBM Registry

Office of Cooperative Research


Dr. Kevin C. O’Connor is an Associate Professor of Neurology at Yale School of Medicine. His investigative interests are in human translational immunology and neurology. Dr. O’Connor earned a Bachelor of Science degree in Chemistry from the University of Massachusetts at Amherst and his Ph.D. in Biochemistry at Tufts Medical School. While at Tufts he studied the role of the developing immune system in autoimmune pathology. In 2000 he joined the laboratory of Dr. David Hafler at Harvard Medical School to begin his post-doctoral training. During this period he initiated a program aimed at understanding the role that B cells and autoantibodies play in the pathogenesis of multiple sclerosis (MS). His group helped define the autoantibody repertoire in MS and a number of inflammatory neurologic diseases. In 2007 he became an Assistant Professor of Neurology at Harvard Medical School. His laboratory focused their efforts toward studying the immune response that occurs in autoimmune tissue and certain tumors. He and his team were among the first to characterize tertiary lymphoid tissue in germ cell tumors. They also described the molecular characteristics of plasma cells that populate the muscle tissue of patients with myositis. They refined the role of Epstein-Barr virus in the MS brain and have begun to define the role of humoral immunity in children with MS. Recently, he and his team identified a network of B cells and antibodies that populate the MS central nervous system. His current research is focused on identifying the molecular entities that initiate and sustain the autoimmune response in MS, myositis, myasthenia gravis and tumors. He and his laboratory moved to Yale in early 2010 where they continue these investigations.

Education & Training

PhD Tufts University (1999)
BS University of Massachusetts at Amherst (1988)

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