The Aging Female Gamete

Understanding why the oocytes of older women loose their viability and are more prone to chromosomal abnormalities. Our research in this area involves examining the role of key DNA repair mechanisms and how they function during oogenesis. We are also investigating ways in which we can treat women of advanced age achieve successful pregnancies.

Figure: Poly(ADP-ribosyl)ation [one of the main mechanisms of base excision repair or the DNA] during oogenesis in the mouse.