The Design and Synthesis of Steroidal Probes

Our goals are to design and synthesize analogs of steroid hormones as therapeutic agents and probes for research and clinical studies.

An important goal of this laboratory is the synthesis of an estrogen that acts solely within the area to which administered, a locally active estrogen. This estrogen is in the family known as “soft drugs” and would be useful for several syndromes and symptoms of estrogen deprivation common to the menopause or through therapeutic intervention by surgery or drugs. One of the well-known effects of estrogen deprivation caused by the menopause is vaginal dyspareunia (atrophy), a disorder which eventually affects a large proportion of all women.

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