Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucose; Hypoglycemia; Insulin; Pediatrics; Pancreas, Artificial
Office of Research Services
The entire focus of our research is to evaluate improved ways to treat children and adolescents with diabetes and related disorders such as childhood obesity. These studies span the spectrum of clinical research from testing of advances in diabetes technology directed at the development of an artificial pancreas to behavoral interventions aimed at improved outcomes with current therapies. Our center has been at the forefront of pediatric diabetes research for many years.
Specialized Terms: Advances in the treatment of type 1 and 2 diabetes; Counterregulatory Hormone Responses to Hypoglycemia; Psychosocial Consequences of Diabetes; Behavioral Interventions in Diabetes; insulin pumps; continuous glucose monitoring; artificial pancreas development
Extensive Research Description
Dr. William Tamborlane studies diabetes and metabolism in children. He directs the Yale Center in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. Dr. Tamborlane's ongoing project regarding the prevention of hypoglycemia is funded within The Yale Juvenile Diabetes Research Foundation Center grant for the study of hypoglycemia. Dr. Tamborlane is Co-Program Director of the Combined Adult and Pediatric training grant in endocrinology/diabetes from the NIH/NIDDK, as well as Program Director of the Yale Pediatric Diabetes Career Development K12 program from NIH/NIDDK . He is Deputy Director, Yale Center for Clinical Investigation that is transforming the support that is provided for clinical research across the entire medical center campus. In April 2006 he received the prestigious Mary Tyler Moore and S. Robert Levine Excellence in Clinical Research Award from the Juvenile Diabetes Research Foundation International at its annual meeting in Washington, D.C. In 2009 Dr. Tamborlane received the Diabetes Technology Society Leadership Award and in 2010 the American Diabetes Association Outstanding Clinician Physician in Diabetes Award and in 2014 he received the Career Achievement Award from the International Society for Pediatric and Adolescent Diabetes (ISPAD). he is the author or co-author of more than 850 publications related to diabetes and related disorders.
- continuous glucose monitoring studies
- insulin pump studies
- artificial pancreas studies
- insulin pharmacokinetic and pharmacodynamic studies
- hypoglycemia studies
Insulin-infusion-pump treatment of diabetes: influence of improved metabolic control on plasma somatomedin levels
Tamborlane WV, Hintz RL, Bergman M, Genel M, Felig P, Sherwin RS. N Engl J Med 1981 Aug 6;305(6):303-7.
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993 Sep 30;329(14):977-86.
Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial
Diabetes Control and Complications Research Group. J Pediatr. 1994 Aug;125(2):177-88.
Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes
Amiel SA, Sherwin RS, Simonson DC, Lauritano AA, Tamborlane WV. N Engl J Med. 1986 Jul 24;315(4):215-9.
Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion
Merkel PA, Simonson DC, Amiel SA, Plewe G, Sherwin RS, Pearson HA, Tamborlane WV. N Engl J Med. 1988 Mar 31;318(13):809-14
Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus
Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS. N Engl J Med. 1987 May 28;316(22):1376-83
Decreased epinephrine responses to hypoglycemia during sleep
Jones TW, Porter P, Sherwin RS, Davis EA, O'Leary P, Frazer F, Byrne G, Stick S, Tamborlane WV. N Engl J Med. 1998 Jun 4;338(23):1657-62.
Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump
Tamborlane WV, Sherwin RS, Genel M, Felig P. N Engl J Med. 1979 Mar 15;300(11):573-8
Reduced hypoglycemia and increased time in target using closed-loop insulin delivery during nights with or without antecedent afternoon exercise in type 1 diabetes
Sherr JL, Cengiz E, Palerm CC, Clark B, Kurtz N, Roy A, Carria L, Cantwell M, Tamborlane WV, Weinzimer SA. Diabetes Care. 2013 Oct;36(10):2909-14. doi: 10.2337/dc13-0010
Lack of association between residual insulin production and glucagon response to typoglycemia in youth with short duration of type 1 diabetes
Sherr J, Xing D, Ruedy KJ, Beck RW, Kollman C, Buckingham B, White NH, Fox L, Tsalikian E, Weinzimer S, Arbelaez AM, Tamborlane WV; Diabetes in Children Network. Diabetes Care. 2013 Jun;36(6):1470-6. doi: 10.2337/dc12-1697
Continuous glucose monitoring and intensive treatment of type 1 diabetes
Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group., Tamborlane WV, Beck RW, Bode BW, Buckingham B, Clemons R, Fiallo-Scharer R, Fox LA, Gilliam LK, Hirsch IB, Huang ES, Kollman C, Kowalski AJ, Laffel L, Lawrence JM, Lee J, Mauras N, O'Grady M, Ruedy KJ, Tansey M, Tsalikian E, Weinzimer S, Wilson DM, Wolpert H, Wysocki T, Xing D. N Engl J Med. 2008 Oct 2;359(14):1464-76. doi: 10.1056/NEJMoa0805017.
Fully automated closed-loop insulin delivery versus semiautomated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas
Weinzimer SA, Steil GM, Swan KL, Dziura J, Kurtz N, Tamborlane WV. Diabetes Care. 2008 May;31(5):934-9. doi: 10.2337/dc07-1967.
Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes
Bergenstal RM, Tamborlane WV, Ahmann A, Buse JB, Dailey G, Davis SN, Joyce C, Peoples T, Perkins BA, Welsh JB, Willi SM, Wood MA; STAR 3 Study Group. N Engl J Med. 2010 Jul 22;363(4):311-20. doi: 10.1056/NEHMoa1002853. Erratum in: N Engl J Med. 2010 Sep 9;363(11):1092.
Effect of pramlintide on prandial glycemic excursions during closed-loop control in adolescents and young adults with type 1 diabetes
Weinzimer SA, Sherr JL, Cengiz E, Kim G, Ruiz JL, Carria L, Voskanyan G, Roy A, Tamborlane WV. Diabetes Care. 2012 Oct;35(10):1994-9.
Safety of nighttime 2-hour suspension of Basal insulin in pump-treated type 1 diabetes even in the absence of low glucose
Sherr JL, Palau Collazo M, Cengiz E, Michaud C, Carria L, Steffen AT, Weyman K, Zgorski M, Tichy E, Tamborlane WV, Weinzimer SA. Diabetes Care. 2014;37;(3):773-9. doi: 10.2337/dc13-1608.
Obesity and the Metabolic syndrome in children and adolescents
Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. N Engl J Med. 2004 Jun 3;350(23):2362-74.
Effects of a weight management program on body composition and metabolic parameters in overweight children: a randomized controlled trial
Savoye M, Shaw M, Dziura J, Tamborlane WV, Rose P, Guandalini C, Goldberg-Gell R, Burgert TS, Cali AM, Weiss R, Caprio S. JAMA. 2007 Jun 27;297(24):2697-704.
A clinical trial to maintain glycemic control in youth with type 2 diabetes
TODAY Study Group., Zeitler P, Hirst K, Pyle L, Linder B, Copeland K, Arslanian S, Cuttler L, Nathan DM, Tollefsen S, Wilfley D, Kaufman F. N Engl J Med. 2012 Jun 14;366(24):2247-56. doi: 10.1056/NEJMoa1109333.
Crisis in care: limited treatment options for type 2 diabetes in adolescents and youth
Tamborlane WV, Klingensmith G. Diabetes Care. 2013 Jun;36(6):1777-8. doi: 10.2337/dc13-0743
Reversal of early abnormalities in glucose metabolism in obese youth: results of an intensive lifestyle randomized controlled study
Savoye M, Caprio S, Dziura J, Camp A, Germain G, Summers C, Li F, Shaw M, Nowicka P, Kursawe R, Depourcq F, Kim G, Tamborlane WV. Diabetes Care. 2014 Feb;27(2):317-24. doi: 10.2337/dc13-1571.