Dopamine; Neurosurgery; Parkinson Disease; Psychiatry; Spinal Cord Injuries; Stem Cells; Neurodegenerative Diseases
Stem Cell Center, Yale: Stem Cells and Tissue Repair | Tissue Specific Stem Cells
Research interests and ongoing projects include the study of cell replacement and gene therapies for Parkinson's disease, amyotrophic lateral sclerosis, other neurodegenerative diseases, and spinal cord injuries, and the study of plasticity and function of central catecholaminergic systems in primates and humans.
Specialized Terms: Dopamine; Fetal Neural Tissue; Gene Therapy; MPTP Primate Model; Neural Grafts; Parkinson's Disease; Stem Cell
- Redmond, D. E., Jr. (2011). Behavioral assessment in the African green monkey after MPTP Administration. Neuromethods. E. Lane and S. Dunnett, Springer Science. 61: 401-435.
- Hurley, P. J., J. D. Elsworth, et al. (2011). "Aged monkeys as a partial model for Parkinson's disease." Pharmacol Biochem Behav 99(3): 324-332.
- Markakis, E. A., K. P. Vives, et al. (2010). "Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain." Mol Ther 18(3): 588-593.
- Redmond, D. E., Jr., S. Weiss, et al. (2010). "Cellular repair in the parkinsonian nonhuman primate brain." Rejuvenation Res 13(2-3): 188-194.
- D.E. Redmond, Jr., J.D. Elsworth, R.H. Roth, C. Leranth, T.J. Collier, B. Blanchard, K.B. Bjugstad, R.J. Samulski, P. Aebischer, J.R. Sladek, Jr, (2009) Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF, Journal of Comp Neurology, Vol 515:31-40 PMID: 19399891
- Elsworth JD, Redmond DE Jr, Leranth C, Bjugstad KB, Sladek JR Jr, Collier TJ, Foti SB, Samulski RJ, Vives KP, Roth RH, (2008). AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons. Exp Neurol. 2008 May;211(1):252-8 PMID: 18346734
- Redmond, DE, Jr (2007) Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells, Proc Natl Acad Sci U S A, 104(29)12175-80
- Sondhi, D (2005) AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL, Gene Therapy, 12(22)1618-21
- Redmond DE Jr, Zhao JL, Randall JD, Eklund AC, Eusebi LO, Roth RH, Gullans SR, Jensen RV, Spatiotemporal patterns of gene expression during fetal monkey brain development, Brain Research. Developmental Brain Research, 146(1-2):99-106, December 2003
- Teng YD, Benn SC, Kalkanis SN, Shefner JM, Onario RC, Cheng B, Lachyanker MB, Macconi M, Maragakis NJ, Llado J, Erkmen K, Redmond DE, Jr, Sidman RL, Przedborski S, Rothstein JD, Brown RH Jr, Snyder EY: Neural stem cells, acting through multiple mechanisms, extensively prolong life and preserve function in a mouse model of ALS. Science Translational Medicine 2012. Epub 2012 Oct 5.
- Elsworth JD, Leranth C, Redmond DE, Jr., Roth RH: Loss of asymmetric spine synapses in prefrontal cortex of motor-asymptomatic, dopamine-depleted, cognitively impaired MPTP-treated monkeys. Int J Neuropsychopharmacol. 2012 Sep 4:1-8. [Epub ahead of print]
- Redmond, D.E. Jr, Caleb R.S. McEntire, Joseph P. Kingsbery, Csaba Leranth, John D. Elsworth, Kimberly B. Bjugstad, Robert H. Roth, Richard J. Samulski, John R. Sladek, Jr. Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced non-human primate Parkinson's model. Molecular Therapy, 2013, in press.
- Bloch, J, Brunet, JF, McEntire, CRS, Redmond, DE, Jr.: Primate adult brain cell autotransplantation produces behavioral and biological recovery in MPTP-induced Parkinsonian St. Kitts monkeys. Journal of Comparative Neurology 2014; 522(12):2729-40 PMID:24610674
- Dirren E, Towne CL, Setola V, Redmond DE Jr., Scheider BL, Aebischer P: Intracerebroventricular injection of AAV6 and AAV9 vectors for cell type specific transgene expression in the spinal cord. Human Gene Therapy 2014; 25(2):109-120
- Wakeman DR, Redmond DE Jr., Snyder EY: Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF over-expression and project neurites toward an appropriate target. Stem Cells Translational Medicine 2014; 3(6):692 PMID:24744393
- Wakeman DR, Weiss S, Sladek JR, Elsworth JD, Bauereis B, Leranth C, Hurley PJ, Roth RH, Redmond DE Jr.: Survival and integration of neurons derived from human embryonic stem cells in MPTP lesioned primates. Cell Transplantation 2014; 23(8):921-1044 PMID: 23562290
- Bubak, A et al.: A potential compensatory role for endogenous striatal tyrosine hydroxylase-positive neurons in a non-human primate model of Parkinson’s disease. Cell Transplantation, 2015 24(4): 673-80.