D. Eugene Redmond Jr. MD
Professor of Psychiatry and of Neurosurgery
Dopamine; Fetal Neural Tissue; Gene Therapy; MPTP Primate Model; Neural Grafts; Parkinson's Disease; Stem Cell
Research interests and ongoing projects include the study of cell replacement and gene therapies for Parkinson's disease, amyotrophic lateral sclerosis, other neurodegenerative diseases, and spinal cord injuries, and the study of plasticity and function of central catecholaminergic systems in primates and humans.
- Redmond, D. E., Jr. (2011). Behavioral assessment in the African green monkey after MPTP Administration. Neuromethods. E. Lane and S. Dunnett, Springer Science. 61: 401-435.
- Hurley, P. J., J. D. Elsworth, et al. (2011). "Aged monkeys as a partial model for Parkinson's disease." Pharmacol Biochem Behav 99(3): 324-332.
- Markakis, E. A., K. P. Vives, et al. (2010). "Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain." Mol Ther 18(3): 588-593.
- Redmond, D. E., Jr., S. Weiss, et al. (2010). "Cellular repair in the parkinsonian nonhuman primate brain." Rejuvenation Res 13(2-3): 188-194.
- D.E. Redmond, Jr., J.D. Elsworth, R.H. Roth, C. Leranth, T.J. Collier, B. Blanchard, K.B. Bjugstad, R.J. Samulski, P. Aebischer, J.R. Sladek, Jr, (2009) Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF, Journal of Comp Neurology, Vol 515:31-40 PMID: 19399891
- Elsworth JD, Redmond DE Jr, Leranth C, Bjugstad KB, Sladek JR Jr, Collier TJ, Foti SB, Samulski RJ, Vives KP, Roth RH, (2008). AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons. Exp Neurol. 2008 May;211(1):252-8 PMID: 18346734
- Redmond, DE, Jr (2007) Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells, Proc Natl Acad Sci U S A, 104(29)12175-80
- Sondhi, D (2005) AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL, Gene Therapy, 12(22)1618-21
- Redmond DE Jr, Zhao JL, Randall JD, Eklund AC, Eusebi LO, Roth RH, Gullans SR, Jensen RV, Spatiotemporal patterns of gene expression during fetal monkey brain development, Brain Research. Developmental Brain Research, 146(1-2):99-106, December 2003