Bing Wu, PhD
Postdoctoral Associate
Research & Publications
Biography
Selected Publications
- Hemin protects UVB-induced skin damage through inhibiting keratinocytes apoptosis and reducing neutrophil infiltration.Bai F, Fan C, Lin X, Wang HY, Wu B, Feng CL, Zhou R, Wu YW, Tang W. Hemin protects UVB-induced skin damage through inhibiting keratinocytes apoptosis and reducing neutrophil infiltration. J Photochem Photobiol B 2023, 238: 112604. PMID: 36525776, DOI: 10.1016/j.jphotobiol.2022.112604.
- STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion.Wu B, Xu MM, Fan C, Feng CL, Lu QK, Lu HM, Xiang CG, Bai F, Wang HY, Wu YW, Tang W. STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion. Acta Pharmacol Sin 2022, 43: 2055-2066. PMID: 34907359, DOI: 10.1038/s41401-021-00813-2.
- Hemin protects against Zika virus infection by disrupting virus-endosome fusion.Xu MM, Wu B, Huang GG, Feng CL, Wang XH, Wang HY, Wu YW, Tang W. Hemin protects against Zika virus infection by disrupting virus-endosome fusion. Antiviral Res 2022, 203: 105347. PMID: 35643150, DOI: 10.1016/j.antiviral.2022.105347.
- Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells.Lu QK, Fan C, Xiang CG, Wu B, Lu HM, Feng CL, Yang XQ, Li H, Tang W. Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells. Acta Pharmacol Sin 2022, 43: 376-386. PMID: 33850274, DOI: 10.1038/s41401-021-00656-x.
- A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage.Huang S, Wu Y, Zhao Z, Wu B, Sun K, Wang H, Qin L, Bai F, Leng Y, Tang W. A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage. Metabolism 2021, 120: 154797. PMID: 33984334, DOI: 10.1016/j.metabol.2021.154797.
- Synthesis and Pharmacological Evaluation of Tetrahydro-γ-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase.Tan J, Wu B, Chen T, Fan C, Zhao J, Xiong C, Feng C, Xiao R, Ding C, Tang W, Zhang A. Synthesis and Pharmacological Evaluation of Tetrahydro-γ-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase. J Med Chem 2021, 64: 7667-7690. PMID: 34044539, DOI: 10.1021/acs.jmedchem.1c00398.
- Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage.Wu B, Wu Y, Fan C, Feng C, Wang H, Bai F, Zuo J, Tang W. Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage. Int Immunopharmacol 2021, 94: 107482. PMID: 33639567, DOI: 10.1016/j.intimp.2021.107482.
- Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way.Wu Y, Wu B, Zhang Z, Lu H, Fan C, Qi Q, Gao Y, Li H, Feng C, Zuo J, Tang W. Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way. FASEB J 2020, 34: 8028-8043. PMID: 32301543, DOI: 10.1096/fj.202000313RR.
- Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an o-Aminopyridyl Alkynyl Scaffold as Potential Treatment for Inflammatory Disorders.Xie Z, Wu B, Liu Y, Ren W, Tong L, Xiang C, Wei A, Gao Y, Zeng L, Xie H, Tang W, Hu Y. Novel Class of Colony-Stimulating Factor 1 Receptor Kinase Inhibitors Based on an o-Aminopyridyl Alkynyl Scaffold as Potential Treatment for Inflammatory Disorders. J Med Chem 2020, 63: 1397-1414. PMID: 31934767, DOI: 10.1021/acs.jmedchem.9b01912.
- DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models.Zhang Z, Wu Y, Wu B, Qi Q, Li H, Lu H, Fan C, Feng C, Zuo J, Niu L, Tang W. DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models. Arthritis Res Ther 2019, 21: 290. PMID: 31842999, DOI: 10.1186/s13075-019-2074-9.
- Heme Catabolic Pathway in Inflammation and Immune Disorders.Wu B, Wu Y, Tang W. Heme Catabolic Pathway in Inflammation and Immune Disorders. Front Pharmacol 2019, 10: 825. PMID: 31396090, DOI: 10.3389/fphar.2019.00825.