Dimitra P. Vageli, PhD

• Benjamin L. Judson
• Jose Costa

Bile Reflux; Carcinogens; Tobacco; NF-kappa B; STAT3 Transcription Factor; DNA Mismatch Repair; Laryngopharyngeal Reflux; Squamous Cell Carcinoma of Head and Neck

Biomarkers; Cancer

• Abstract PO-047: A novel saliva miRNA panel of promising diagnostic biomarkers for oral cancer: The association of miR-21 with smoking historyDimitra Vageli, Panagiotis G. Doukas, Benjamin L. Judson; Abstract PO-047: A novel saliva miRNA panel of promising diagnostic biomarkers for oral cancer: The association of miR-21 with smoking history. Clin Cancer Res 15 September 2023; 29 (18_Supplement): PO–047. https://doi.org/10.1158/1557-3265.AACRAHNS23-PO-047
• A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study.Vageli D, Doukas P, Shah R, Boyi T, Liu C, Judson B. A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study. Cancer Prevention Research 2023, 16: 653-659. PMID: 37683274, DOI: 10.1158/1940-6207.capr-23-0219.
• Head and neck follicular lymphoma with marginal zone differentiation and BCL2 translocation t(14;18) in both nodular and extranodular sites: a case report with mini-reviewVageli D, Doukas P, Batrakouli O, Tsangari V, Zacharouli K, Pouliou E, Tzika S, Ioannou M. Head and neck follicular lymphoma with marginal zone differentiation and BCL2 translocation t(14;18) in both nodular and extranodular sites: a case report with mini-review. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 2023, 136: e139-e148. PMID: 37516620, DOI: 10.1016/j.oooo.2023.05.005.
• Exosomal MicroRNA-223, MicroRNA-146, and MicroRNA-21 Profiles and Biochemical Changes in Laryngeal CancerGenc S, Yagci T, Vageli D, Dundar R, Doukas P, Doukas S, Tolia M, Chatzakis N, Tsatsakis A, Taghizadehghalehjoughi A. Exosomal MicroRNA-223, MicroRNA-146, and MicroRNA-21 Profiles and Biochemical Changes in Laryngeal Cancer. ACS Pharmacology & Translational Science 2023, 6: 820-828. PMID: 37200807, PMCID: PMC10186621, DOI: 10.1021/acsptsci.3c00038.
• Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review)Doukas S, Doukas P, Vageli D, Broder A. Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review). Obesity Surgery 2023, 33: 1876-1888. PMID: 37041375, DOI: 10.1007/s11695-023-06567-6.
• Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New InsightsVageli D, Doukas P, Zacharouli K, Kakanis V, Strataki M, Zioga A, Skoulakis C, Koukoulis G, Ioannou M. Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights. Head And Neck Pathology 2022, 17: 331-338. PMID: 36303015, PMCID: PMC10293497, DOI: 10.1007/s12105-022-01504-y.
• The Role of PARP‐1 and NF‐κB in Bile‐Induced DNA Damage and Oncogenic Profile in Hypopharyngeal CellsDoukas PG, Vageli DP, Judson BL. The Role of PARP‐1 and NF‐κB in Bile‐Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells. The Laryngoscope 2022, 133: 1146-1155. PMID: 35791892, DOI: 10.1002/lary.30284.
• Patient with prostatic adenocarcinoma with plasmacytoid features and an aberrant immunohistochemical phenotype diagnosed by biopsy and a mini-review of plasmacytoid features in the genitourinary system: A case report.Zacharouli K, Vageli DP, Koukoulis GK, Ioannou M. Patient with prostatic adenocarcinoma with plasmacytoid features and an aberrant immunohistochemical phenotype diagnosed by biopsy and a mini-review of plasmacytoid features in the genitourinary system: A case report. Molecular And Clinical Oncology 2022, 16: 67. PMID: 35154707, PMCID: PMC8822602, DOI: 10.3892/mco.2022.2500.
• Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo.Vageli DP, Doukas PG, Doukas SG, Tsatsakis A, Judson BL. Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo. Cancer Prevention Research 2022, 15: 297-308. PMID: 35502554, DOI: 10.1158/1940-6207.capr-21-0529.
• Targeting STAT3 prevents bile reflux‐induced oncogenic molecular events linked to hypopharyngeal carcinogenesisVageli DP, Doukas PG, Siametis A, Judson BL. Targeting STAT3 prevents bile reflux‐induced oncogenic molecular events linked to hypopharyngeal carcinogenesis. Journal Of Cellular And Molecular Medicine 2021, 26: 75-87. PMID: 34850540, PMCID: PMC8742186, DOI: 10.1111/jcmm.17011.
• Bile reflux and hypopharyngeal cancerVageli DP, Doukas SG, Doukas PG, Judson BL. Bile reflux and hypopharyngeal cancer. Oncology Reports 2021, 46: 244. PMID: 34558652, PMCID: PMC8485019, DOI: 10.3892/or.2021.8195.
• Controlled ovarian stimulation therapy as a potential risk for the development and progression of renal cell carcinomas: A case report and literature review.Doukas SG, Martinez B, Rosenthal ME, Vageli DP. Controlled ovarian stimulation therapy as a potential risk for the development and progression of renal cell carcinomas: A case report and literature review. Molecular And Clinical Oncology 2021, 15: 140. PMID: 34094538, PMCID: PMC8165689, DOI: 10.3892/mco.2021.2302.
• Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal CellsDoukas PG, Vageli DP, Sasaki CT, Judson BL. Pepsin Promotes Activation of Epidermal Growth Factor Receptor and Downstream Oncogenic Pathways, at Slightly Acidic and Neutral pH, in Exposed Hypopharyngeal Cells. International Journal Of Molecular Sciences 2021, 22: 4275. PMID: 33924087, PMCID: PMC8074291, DOI: 10.3390/ijms22084275.
• Weakly Acidic Bile Is a Risk Factor for Hypopharyngeal Carcinogenesis Evidenced by DNA Damage, Antiapoptotic Function, and Premalignant Dysplastic Lesions In VivoSasaki CT, Doukas SG, Doukas PG, Vageli DP. Weakly Acidic Bile Is a Risk Factor for Hypopharyngeal Carcinogenesis Evidenced by DNA Damage, Antiapoptotic Function, and Premalignant Dysplastic Lesions In Vivo. Cancers 2021, 13: 852. PMID: 33670587, PMCID: PMC7923205, DOI: 10.3390/cancers13040852.
• SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19Tsatsakis A, Calina D, Falzone L, Petrakis D, Mitrut R, Siokas V, Pennisi M, Lanza G, Libra M, Doukas SG, Doukas PG, Kavali L, Bukhari A, Gadiparthi C, Vageli DP, Kofteridis DP, Spandidos DA, Paoliello MMB, Aschner M, Docea AO. SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19. Food And Chemical Toxicology 2020, 146: 111769. PMID: 32979398, PMCID: PMC7833750, DOI: 10.1016/j.fct.2020.111769.
• The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical modelVageli DP, Kasle D, Doukas SG, Doukas PG, Sasaki CT. The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model. Oncotarget 2020, 11: 3303-3314. PMID: 32934775, PMCID: PMC7476734, DOI: 10.18632/oncotarget.27706.
• The in vivo preventive and therapeutic properties of curcumin in bile reflux‐related oncogenesis of the hypopharynxDoukas SG, Doukas PG, Sasaki CT, Vageli D. The in vivo preventive and therapeutic properties of curcumin in bile reflux‐related oncogenesis of the hypopharynx. Journal Of Cellular And Molecular Medicine 2020, 24: 10311-10321. PMID: 32691972, PMCID: PMC7521262, DOI: 10.1111/jcmm.15640.
• The role of bile reflux and its related NF-κB activated pathway in progression of hypopharyngeal squamous cell cancer.Sasaki CT, Hajek M, Doukas SG, Vageli DP. The role of bile reflux and its related NF-κB activated pathway in progression of hypopharyngeal squamous cell cancer. Oral Oncology 2020, 105: 104668. PMID: 32247988, DOI: 10.1016/j.oraloncology.2020.104668.
• The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New InsightsSasaki CT, Doukas SG, Costa J, Vageli DP. The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights. Cancers 2020, 12: 1064. PMID: 32344873, PMCID: PMC7281001, DOI: 10.3390/cancers12051064.
• The Effect of NNK, A Tobacco Smoke Carcinogen, on the miRNA and Mismatch DNA Repair Expression Profiles in Lung and Head and Neck Squamous Cancer Cells.Doukas SG, Vageli DP, Lazopoulos G, Spandidos DA, Sasaki CT, Tsatsakis A. The Effect of NNK, A Tobacco Smoke Carcinogen, on the miRNA and Mismatch DNA Repair Expression Profiles in Lung and Head and Neck Squamous Cancer Cells. Cells 2020, 9 PMID: 32326378, PMCID: PMC7226174, DOI: 10.3390/cells9041031.
• Rare amyloidoma of the tongue base: A case report and review of the literature.Musat G, Evsei A, Calina D, Docea AO, Doukas SG, Vageli DP, Nepka C, Spandidos DA, Mitroi M. Rare amyloidoma of the tongue base: A case report and review of the literature. Molecular And Clinical Oncology 2020, 12: 258-262. PMID: 32064103, PMCID: PMC7016517, DOI: 10.3892/mco.2020.1972.
• Biliary tumorigenic effect on hypopharyngeal cells is significantly enhanced by pH reduction.Doukas SG, Cardoso B, Tower JI, Vageli DP, Sasaki CT. Biliary tumorigenic effect on hypopharyngeal cells is significantly enhanced by pH reduction. Cancer Medicine 2019, 8: 4417-4427. PMID: 31173474, PMCID: PMC6675744, DOI: 10.1002/cam4.2194.
• Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implicationsSasaki CT, Doukas SG, Costa J, Vageli DP. Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications. Cancer 2019, 125: 3554-3565. PMID: 31310330, DOI: 10.1002/cncr.32369.
• Temporal characteristics of NF-κB inhibition in blocking bile-induced oncogenic molecular events in hypopharyngeal cellsDoukas PG, Vageli DP, Doukas SG, Sasaki CT. Temporal characteristics of NF-κB inhibition in blocking bile-induced oncogenic molecular events in hypopharyngeal cells. Oncotarget 2019, 10: 3339-3351. PMID: 31164956, PMCID: PMC6534360, DOI: 10.18632/oncotarget.26917.
• Role of DNA mismatch repair genes in lung and head and neck cancer (Review)Doukas, S.G., Vageli, D.P., Nikolouzakis, T.K., Falzone, L., Docea, A.O., Lazopoulos, G. ... Tsatsakis, A. (2019). Role of DNA mismatch repair genes in lung and head and neck cancer (Review). World Academy of Sciences Journal, 1, 184-191. https://doi.org/10.3892/wasj.2019.21
• Curcumin prevents the bile reflux-induced NF-κB-related mRNA oncogenic phenotype, in human hypopharyngeal cells.Vageli DP, Doukas SG, Spock T, Sasaki CT. Curcumin prevents the bile reflux-induced NF-κB-related mRNA oncogenic phenotype, in human hypopharyngeal cells. Journal Of Cellular And Molecular Medicine 2018, 22: 4209-4220. PMID: 29911313, PMCID: PMC6111812, DOI: 10.1111/jcmm.13701.
• NF-κB inhibition reverses acidic bile-induced miR-21, miR-155, miR-192, miR-34a, miR-375 and miR-451a deregulations in human hypopharyngeal cells.Doukas SG, Vageli DP, Sasaki CT. NF-κB inhibition reverses acidic bile-induced miR-21, miR-155, miR-192, miR-34a, miR-375 and miR-451a deregulations in human hypopharyngeal cells. Journal Of Cellular And Molecular Medicine 2018, 22: 2922-2934. PMID: 29516639, PMCID: PMC5908126, DOI: 10.1111/jcmm.13591.
• In Vivo Short-Term Topical Application of BAY 11-7082 Prevents the Acidic Bile-Induced mRNA and miRNA Oncogenic Phenotypes in Exposed Murine Hypopharyngeal Mucosa.Sasaki CT, Doukas SG, Vageli DP. In Vivo Short-Term Topical Application of BAY 11-7082 Prevents the Acidic Bile-Induced mRNA and miRNA Oncogenic Phenotypes in Exposed Murine Hypopharyngeal Mucosa. Neoplasia (New York, N.Y.) 2018, 20: 374-386. PMID: 29529473, PMCID: PMC5909679, DOI: 10.1016/j.neo.2018.02.001.
• Inhibition of NF-κB prevents the acidic bile-induced oncogenic mRNA phenotype, in human hypopharyngeal cells.Vageli DP, Doukas SG, Sasaki CT. Inhibition of NF-κB prevents the acidic bile-induced oncogenic mRNA phenotype, in human hypopharyngeal cells. Oncotarget 2018, 9: 5876-5891. PMID: 29464041, PMCID: PMC5814181, DOI: 10.18632/oncotarget.23143.
• miR-21, miR-155, miR-192, and miR-375 Deregulations Related to NF-kappaB Activation in Gastroduodenal Fluid-Induced Early Preneoplastic Lesions of Laryngeal Mucosa In Vivo.Sasaki CT, Vageli DP. miR-21, miR-155, miR-192, and miR-375 Deregulations Related to NF-kappaB Activation in Gastroduodenal Fluid-Induced Early Preneoplastic Lesions of Laryngeal Mucosa In Vivo. Neoplasia (New York, N.Y.) 2016, 18: 329-38. PMID: 27292022, PMCID: PMC4909705, DOI: 10.1016/j.neo.2016.04.007.
• In vitro model for gastroduodenal reflux-induced nuclear factor-kappaB activation and its role in hypopharyngeal carcinogenesis.Sasaki CT, Issaeva N, Vageli DP. In vitro model for gastroduodenal reflux-induced nuclear factor-kappaB activation and its role in hypopharyngeal carcinogenesis. Head & Neck 2016, 38 Suppl 1: E1381-91. PMID: 26559497, DOI: 10.1002/hed.24231.
• Gastro-duodenal fluid induced nuclear factor- κappa B activation and early pre-malignant alterations in murine hypopharyngeal mucosaVageli DP, Prasad ML, Sasaki CT. Gastro-duodenal fluid induced nuclear factor- κappa B activation and early pre-malignant alterations in murine hypopharyngeal mucosa. Oncotarget 2016, 7: 5892-5908. PMID: 26745676, PMCID: PMC4868729, DOI: 10.18632/oncotarget.6824.
• The In Vitro Effect of Acidic-Pepsin on Nuclear Factor KappaB Activation and Its Related Oncogenic Effect on Normal Human Hypopharyngeal Cells.Sasaki CT, Toman J, Vageli D. The In Vitro Effect of Acidic-Pepsin on Nuclear Factor KappaB Activation and Its Related Oncogenic Effect on Normal Human Hypopharyngeal Cells. PloS One 2016, 11: e0168269. PMID: 27973541, PMCID: PMC5156414, DOI: 10.1371/journal.pone.0168269.
• Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaquesVAGELI DP, EXARCHOU A, ZAFIRIOU E, DOUKAS PG, DOUKAS S, ROUSSAKI-SCHULZE A. Effect of TNF-α inhibitors on transcriptional levels of pro-inflammatory interleukin-33 and Toll-like receptors-2 and -9 in psoriatic plaques. Experimental And Therapeutic Medicine 2015, 10: 1573-1577. PMID: 26622528, PMCID: PMC4577938, DOI: 10.3892/etm.2015.2688.
• Mismatch DNA repair mRNA expression profiles in oral melanin pigmentation lesion and hamartomatous polyp of a child with Peutz-Jeghers syndrome.Vageli DP, Doukas SG, Markou A. Mismatch DNA repair mRNA expression profiles in oral melanin pigmentation lesion and hamartomatous polyp of a child with Peutz-Jeghers syndrome. Pediatric Blood & Cancer 2013, 60: E116-7. PMID: 23677888, DOI: 10.1002/pbc.24579.
• hMSH2 and hMLH1 gene expression patterns differ between lung adenocarcinoma and squamous cell carcinoma: correlation with patient survival and response to adjuvant chemotherapy treatment.Vageli DP, Zaravinos A, Daniil Z, Dahabreh J, Doukas SG, Spandidos DA, Gourgoulianis KI, Koukoulis GK. hMSH2 and hMLH1 gene expression patterns differ between lung adenocarcinoma and squamous cell carcinoma: correlation with patient survival and response to adjuvant chemotherapy treatment. The International Journal Of Biological Markers 2013, 27: e400-4. PMID: 22865300, DOI: 10.5301/JBM.2012.9420.
• Mismatch repair hMSH2, hMLH1, hMSH6 and hPMS2 mRNA expression profiles in precancerous and cancerous urothelium.Vageli DP, Giannopoulos S, Doukas SG, Kalaitzis C, Giannakopoulos S, Giatromanolaki A, Koukoulis GK, Touloupidis S. Mismatch repair hMSH2, hMLH1, hMSH6 and hPMS2 mRNA expression profiles in precancerous and cancerous urothelium. Oncology Letters 2013, 5: 283-294. PMID: 23255936, PMCID: PMC3525358, DOI: 10.3892/ol.2012.979.
• HPV6 Infection of an Infant’s Penile Condyloma at the Urethral MeatusDP Vageli, SG Doukas, A Markou. HPV6 Infection of an Infant’s Penile Condyloma at the Urethral Meatus. J Genet Syndr Gene Ther 2013; 4(157): 2.
• Mismatch DNA repair hMSH2, hMLH1, hMSH6 and hPMS2 mRNA expression profiles in colorectal carcinomasDP Vageli, R Papamichali, K Kambosioras, CN Papandreou, GK Koukoulis. Mismatch DNA repair hMSH2, hMLH1, hMSH6 and hPMS2 mRNA expression profiles in colorectal carcinomas. J. Genet. Syndr. Gene Ther. 2013; 4(10), 1000191.
• Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma.Ioannou M, Papamichali R, Kouvaras E, Mylonis I, Vageli D, Kerenidou T, Barbanis S, Daponte A, Simos G, Gourgoulianis K, Koukoulis GK. Hypoxia inducible factor-1 alpha and vascular endothelial growth factor in biopsies of small cell lung carcinoma. Lung 2009, 187: 321-9. PMID: 19707816, DOI: 10.1007/s00408-009-9169-z.
• Phenotypic mismatch repair hMSH2 and hMLH1 gene expression profiles in primary non-small cell lung carcinomas.Vageli D, Daniil Z, Dahabreh J, Karagianni E, Vamvakopoulou DN, Ioannou MG, Scarpinato K, Vamvakopoulos NC, Gourgoulianis KI, Koukoulis GK. Phenotypic mismatch repair hMSH2 and hMLH1 gene expression profiles in primary non-small cell lung carcinomas. Lung Cancer (Amsterdam, Netherlands) 2009, 64: 282-8. PMID: 19056144, DOI: 10.1016/j.lungcan.2008.09.018.
• Transcriptional activation of hTERT in breast carcinomas by the Her2-ER81-related pathway.Vageli D, Ioannou MG, Koukoulis GK. Transcriptional activation of hTERT in breast carcinomas by the Her2-ER81-related pathway. Oncology Research 2009, 17: 413-23. PMID: 19718948, DOI: 10.3727/096504009788912507.
• MSH2 & MLH1 phenotypic profiles of two rare cams of synchronous histomorphologically distinct gastric ademocarcinomas with gastrointestinal stromal tumors of the proximal small bowel: Informative, "all purpose", practical tumor markersVageli, D.; Athanassiou, E.; Koukoulis, G. K. MSH2 & MLH1 phenotypic profiles of two rare cams of synchronous histomorphological distinct gastric adenocarcinomas with gastrointestinal stromal tumors of the proximal small bowel: Informative, "all-purpose", practical tumor markers.
• Geographic variations of human papilloma virus infection and their possible impact on the effectiveness of the vaccination programme.Mammas IN, Vageli D, Spandidos DA. Geographic variations of human papilloma virus infection and their possible impact on the effectiveness of the vaccination programme. Oncology Reports 2008, 20: 141-5. PMID: 18575729.
• Comparative evaluation of non-informative HER-2 immunoreactions (2+) in breast carcinomas with FISH, CISH and QRT-PCR.Kostopoulou E, Vageli D, Kaisaridou D, Nakou M, Netsika M, Vladica N, Daponte A, Koukoulis G. Comparative evaluation of non-informative HER-2 immunoreactions (2+) in breast carcinomas with FISH, CISH and QRT-PCR. Breast (Edinburgh, Scotland) 2007, 16: 615-24. PMID: 17606374, DOI: 10.1016/j.breast.2007.05.008.
• High-risk human papillomavirus (HPV) in parotid lesions.Vageli D, Sourvinos G, Ioannou M, Koukoulis GK, Spandidos DA. High-risk human papillomavirus (HPV) in parotid lesions. The International Journal Of Biological Markers 2007, 22: 239-44. PMID: 18161653, DOI: 10.5301/jbm.2008.2974.
• Microsatellite instability and loss of heterozygosity at the MEN1 locus in lung carcinoid tumors: a novel approach using real-time PCR with melting curve analysis in histopathologic material.Vageli D, Daniil Z, Dahabreh J, Karagianni E, Liloglou T, Koukoulis G, Gourgoulianis K. Microsatellite instability and loss of heterozygosity at the MEN1 locus in lung carcinoid tumors: a novel approach using real-time PCR with melting curve analysis in histopathologic material. Oncology Reports 2006, 15: 557-64. PMID: 16465412.
• Transcriptional activation of H-ras, K-ras and N-ras proto-oncogenes in human bladder tumors.Vageli D, Kiaris H, Delakas D, Anezinis P, Cranidis A, Spandidos DA. Transcriptional activation of H-ras, K-ras and N-ras proto-oncogenes in human bladder tumors. Cancer Letters 1996, 107: 241-7. PMID: 8947520, DOI: 10.1016/0304-3835(96)04372-8.
• Genomic instability and loh at 2 polymorphic sites in the h-ras1 gene.Kotsinas A, Vageli D, Varakliotou A, Anezinis P, Cranidis A, Spandidos D. Genomic instability and loh at 2 polymorphic sites in the h-ras1 gene. International Journal Of Oncology 1994, 5: 1249-53. PMID: 21559705, DOI: 10.3892/ijo.5.6.1249.