John Greg Howe, PhD
Research & Publications
Biography
News
Research Summary
The mission of the Molecular Diagnostics Laboratory is to develop and bring into clinical use already published molecular pathology assays as well as to develop new and innovative molecular tests for the diagnosis of disease and the monitoring of therapy. Various tests have been developed and are in clinical use such as detection of mutations in the prothrombin and Factor V genes that are associated with coagulation abnormalities and tests to determine monoclonality in patients with suspected hematological malignancies. We have applied quantitative polymerase chain reaction (QPCR) methods to the measurement of BCR-ABL translocation as well as less common translocations.
Specialized Terms: Molecular Diagnostics; Hematopathology
Coauthors
Research Interests
Factor V; Prothrombin; Medical Laboratory Science; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Diagnostic Techniques
Selected Publications
- Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survivalSchulz WL, Rinder HM, Durant TJS, Tormey CA, Torres R, Smith BR, Hager KM, Howe JG, Siddon AJ. Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival. Leukemia & Lymphoma 2020, 61: 3269-3271. PMID: 32715805, DOI: 10.1080/10428194.2020.1797016.
- Relationship of epitope glycosylation and other properties of blood group proteins to the immunogenicity of blood group antigensHowe JG, Stack G. Relationship of epitope glycosylation and other properties of blood group proteins to the immunogenicity of blood group antigens. Transfusion 2018, 58: 1739-1751. PMID: 29770450, DOI: 10.1111/trf.14609.
- Structural and functional impacts of amino acid substitutions that create blood group antigens: implications for immunogenicityHowe JG, Stack G. Structural and functional impacts of amino acid substitutions that create blood group antigens: implications for immunogenicity. Transfusion 2017, 57: 541-553. PMID: 28164302, DOI: 10.1111/trf.13966.
- Normalized CCND1 expression has prognostic value in mantle cell lymphomaSiddon AJ, Torres R, Rinder HM, Smith BR, Howe JG, Tormey CA. Normalized CCND1 expression has prognostic value in mantle cell lymphoma. British Journal Of Haematology 2012, 158: 551-553. PMID: 22671703, DOI: 10.1111/j.1365-2141.2012.09181.x.
- Educating Medical Students in Laboratory MedicineSmith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Bock JL, Campbell S, Crookston KP, Fitzgerald R, Fung M, Haspel R, Howe JG, Jhang J, Kamoun M, Koethe S, Krasowski MD, Landry ML, Marques MB, Rinder HM, Roberts W, Schreiber WE, Spitalnik SL, Tormey CA, Wolf P, Wu YY. Educating Medical Students in Laboratory Medicine. American Journal Of Clinical Pathology 2010, 133: 533-542. PMID: 20231605, DOI: 10.1309/ajcpqct94sferlni.
- Comparison of assay systems for warfarin-related CYP2C9 and VKORC1 genotypingMaurice CB, Barua PK, Simses D, Smith P, Howe JG, Stack G. Comparison of assay systems for warfarin-related CYP2C9 and VKORC1 genotyping. Clinica Chimica Acta 2010, 411: 947-954. PMID: 20226775, DOI: 10.1016/j.cca.2010.03.005.