Marc C Llaguno, PhD
Research Scientist in Cell Biology; Manager, Cryo-Electron Microscopy, Cell Biology
Research & Publications
Biography
News
Coauthors
Selected Publications
- Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplexMnatsakanyan N, Park HA, Wu J, He X, Llaguno MC, Latta M, Miranda P, Murtishi B, Graham M, Weber J, Levy RJ, Pavlov EV, Jonas EA. Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplex. Cell Death & Differentiation 2022, 29: 1874-1887. PMID: 35322203, PMCID: PMC9433415, DOI: 10.1038/s41418-022-00972-7.
- Structural and Pharmacological Characterization of the Mitochondrial Permeability Transition Pore: A Megachannel Formed by F1FO ATP SynthaseMnatsakanyan N, Llaguno M, Yang Y, Yan Y, Weber J, Sigworth F, Jonas E. Structural and Pharmacological Characterization of the Mitochondrial Permeability Transition Pore: A Megachannel Formed by F1FO ATP Synthase. Biophysical Journal 2020, 118: 1a. DOI: 10.1016/j.bpj.2019.11.198.
- A mitochondrial megachannel resides in monomeric F1FO ATP synthaseMnatsakanyan N, Llaguno MC, Yang Y, Yan Y, Weber J, Sigworth FJ, Jonas EA. A mitochondrial megachannel resides in monomeric F1FO ATP synthase. Nature Communications 2019, 10: 5823. PMID: 31862883, PMCID: PMC6925261, DOI: 10.1038/s41467-019-13766-2.
- P4‐512: EXCITOTOXIC NEURONAL DEATH INDUCING MEGACHANNEL RESIDES IN MONOMERIC F1FO ATP SYNTHASEMnatsakanyan N, Llaguno M, Yang Y, Yan Y, Sigworth F, Jonas E. P4‐512: EXCITOTOXIC NEURONAL DEATH INDUCING MEGACHANNEL RESIDES IN MONOMERIC F1FO ATP SYNTHASE. Alzheimer's & Dementia 2019, 15: p1509-p1510. DOI: 10.1016/j.jalz.2019.08.058.
- Mitochondrial Megachannel Resides in Monomeric ATP SynthaseMnatsakanyan N, Park H, Jing W, Llaguno M, Murtishi B, Latta M, Davis E, Miranda P, Yang Y, Sigworth F, Jonas E. Mitochondrial Megachannel Resides in Monomeric ATP Synthase. Biophysical Journal 2019, 116: 156a. DOI: 10.1016/j.bpj.2018.11.863.
- Placing and shaping liposomes with reconfigurable DNA nanocagesZhang Z, Yang Y, Pincet F, Llaguno M, Lin C. Placing and shaping liposomes with reconfigurable DNA nanocages. Nature Chemistry 2017, 9: 653-659. PMID: 28644472, PMCID: PMC5542812, DOI: 10.1038/nchem.2802.
- bSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesiclesZheng H, Lee S, Llaguno M, Jiang Q. bSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesicles. Journal Of Cell Biology 2016, 212: 2122oia1. DOI: 10.1083/jcb.2122oia1.
- bSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesiclesZheng H, Lee S, Llaguno MC, Jiang QX. bSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesicles. The Journal Of General Physiology 2015, 147: 77-93. PMID: 26712851, PMCID: PMC4692488, DOI: 10.1085/jgp.201511448.
- Structural Studies of IP3R by CryoemJiang Q, Zheng H, Llaguno M. Structural Studies of IP3R by Cryoem. Biophysical Journal 2015, 108: 340a-341a. DOI: 10.1016/j.bpj.2014.11.1866.
- Chemically functionalized carbon films for single molecule imagingLlaguno MC, Xu H, Shi L, Huang N, Zhang H, Liu Q, Jiang QX. Chemically functionalized carbon films for single molecule imaging. Journal Of Structural Biology 2014, 185: 405-417. PMID: 24457027, PMCID: PMC3990355, DOI: 10.1016/j.jsb.2014.01.006.
- A New Supported Membrane System for Studying the Lipid Effects on a Kv ChannelZheng H, Lee S, Llaguno M, Zhu M, Hilgemann D, Jiang Q. A New Supported Membrane System for Studying the Lipid Effects on a Kv Channel. Biophysical Journal 2014, 106: 298a. DOI: 10.1016/j.bpj.2013.11.1735.
- A Buttressed Unilamellar Membrane System for Studying Lipid-Protein InteractionsLee S, Llaguno M, Jiang Q. A Buttressed Unilamellar Membrane System for Studying Lipid-Protein Interactions. Biophysical Journal 2013, 104: 593a-594a. DOI: 10.1016/j.bpj.2012.11.3297.
- Phase transitions in the assembly of multivalent signalling proteinsLi P, Banjade S, Cheng HC, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK. Phase transitions in the assembly of multivalent signalling proteins. Nature 2012, 483: 336-340. PMID: 22398450, PMCID: PMC3343696, DOI: 10.1038/nature10879.
- Functionalized Ultrathin Carbon Films for Imaging Low-Abundance Biological ComplexesLlaguno M, Xu H, Shi L, Huang N, Zhang H, Liu Q, Jiang Q. Functionalized Ultrathin Carbon Films for Imaging Low-Abundance Biological Complexes. Biophysical Journal 2012, 102: 394a. DOI: 10.1016/j.bpj.2011.11.2151.
- HaloTag® Protein-Mediated Live Cell Imaging with Bigger FluoroNanogold™Joshi V, Jain M, Furuya F, Powell R, Hainfeld J, Llaguno M, Hilgemann D. HaloTag® Protein-Mediated Live Cell Imaging with Bigger FluoroNanogold™. Microscopy And Microanalysis 2011, 17: 150-151. DOI: 10.1017/s1431927611001620.
- Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: a new approach to membrane recycling and lipid domainsFine M, Llaguno M, Lariccia V, Lin M, Yaradanakul A, Hilgemann D. Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: a new approach to membrane recycling and lipid domains. The Journal Of General Physiology 2011, 137: 607-607. PMCID: PMC3105520, DOI: 10.1085/jgp.2010104691376c.
- Massive calcium–activated endocytosis without involvement of classical endocytic proteinsLariccia V, Fine M, Magi S, Lin M, Yaradanakul A, Llaguno M, Hilgemann D. Massive calcium–activated endocytosis without involvement of classical endocytic proteins. The Journal Of General Physiology 2011, 137: 605-605. PMCID: PMC3105511, DOI: 10.1085/jgp.2010104681376c.
- Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: a new approach to membrane recycling and lipid domainsFine M, Llaguno MC, Lariccia V, Lin MJ, Yaradanakul A, Hilgemann DW. Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: a new approach to membrane recycling and lipid domains. The Journal Of General Physiology 2011, 137: 137-154. PMID: 21242300, PMCID: PMC3032378, DOI: 10.1085/jgp.201010469.
- Massive calcium–activated endocytosis without involvement of classical endocytic proteinsLariccia V, Fine M, Magi S, Lin MJ, Yaradanakul A, Llaguno MC, Hilgemann DW. Massive calcium–activated endocytosis without involvement of classical endocytic proteins. The Journal Of General Physiology 2010, 137: 111-132. PMID: 21187336, PMCID: PMC3010057, DOI: 10.1085/jgp.201010468.
- Massive Endocytosis Activated by Perturbing the Outer Plasmalemmal MonolayerFine M, Llaguno M, Yaradanakul A, Lariccia V, Magi S, Lin M, Hilgemann D. Massive Endocytosis Activated by Perturbing the Outer Plasmalemmal Monolayer. Biophysical Journal 2010, 98: 502a. DOI: 10.1016/j.bpj.2009.12.2735.
- Massive Endocytosis (MEND) Activated By Ca and Polyamines in Fibroblasts and Cardiac Myocytes: Optical Studies of Membrane and Na/Ca Exchanger (NCX1) Internalization, The Possible Role of Ca-activated Transglutaminase in MEND, and The Possible Function of MEND In Cardiac MyocytesMagi S, Yaradanakul A, Llaguno M, Li M, Shen C, Fine M, Nicoll D, Hilgemann D. Massive Endocytosis (MEND) Activated By Ca and Polyamines in Fibroblasts and Cardiac Myocytes: Optical Studies of Membrane and Na/Ca Exchanger (NCX1) Internalization, The Possible Role of Ca-activated Transglutaminase in MEND, and The Possible Function of MEND In Cardiac Myocytes. Biophysical Journal 2009, 96: 101a. DOI: 10.1016/j.bpj.2008.12.429.
- Observation of Thermopower Oscillations in the Coulomb Blockade Regime in a Semiconducting Carbon NanotubeLlaguno M, Fischer J, Johnson A, Hone J. Observation of Thermopower Oscillations in the Coulomb Blockade Regime in a Semiconducting Carbon Nanotube. Nano Letters 2003, 4: 45-49. DOI: 10.1021/nl0348488.
- Magnetically aligned single wall carbon nanotube films: Preferred orientation and anisotropic transport propertiesFischer J, Zhou W, Vavro J, Llaguno M, Guthy C, Haggenmueller R, Casavant M, Walters D, Smalley R. Magnetically aligned single wall carbon nanotube films: Preferred orientation and anisotropic transport properties. Journal Of Applied Physics 2003, 93: 2157-2163. DOI: 10.1063/1.1536733.
- Thermoelectric Power of p-Doped Single-Wall Carbon Nanotubes and the Role of Phonon DragVavro J, Llaguno M, Fischer J, Ramesh S, Saini R, Ericson L, Davis V, Hauge R, Pasquali M, Smalley R. Thermoelectric Power of p-Doped Single-Wall Carbon Nanotubes and the Role of Phonon Drag. Physical Review Letters 2003, 90: 065503. PMID: 12633300, DOI: 10.1103/physrevlett.90.065503.
- Electrical and Thermal Properties of C60‐filled Single Wall Carbon NanotubesVavro J, Llaguno M, Satishkumar B, Haggenmueller R, Winey K, Luzzi D, Fischer J, Sumanasekera G, Eklund P. Electrical and Thermal Properties of C60‐filled Single Wall Carbon Nanotubes. AIP Conference Proceedings 2002, 633: 127-130. DOI: 10.1063/1.1514089.
- Carbon nanotube composites for thermal managementBiercuk M, Llaguno M, Radosavljevic M, Hyun J, Johnson A, Fischer J. Carbon nanotube composites for thermal management. Applied Physics Letters 2002, 80: 2767-2769. DOI: 10.1063/1.1469696.
- Thermal properties of carbon nanotubes and nanotube-based materialsHone J, Llaguno M, Biercuk M, Johnson A, Batlogg B, Benes Z, Fischer J. Thermal properties of carbon nanotubes and nanotube-based materials. Applied Physics A 2002, 74: 339-343. DOI: 10.1007/s003390201277.
- Electrical and thermal properties of C60-filled single-wall carbon nanotubesVavro J, Llaguno M, Satishkumar B, Luzzi D, Fischer J. Electrical and thermal properties of C60-filled single-wall carbon nanotubes. Applied Physics Letters 2002, 80: 1450-1452. DOI: 10.1063/1.1452788.
- Thermal conductivity of single wall carbon nanotubes: Diameter and annealing dependenceLlaguno M, Hone J, Johnson A, Fischer J. Thermal conductivity of single wall carbon nanotubes: Diameter and annealing dependence. AIP Conference Proceedings 2001, 591: 384-387. DOI: 10.1063/1.1426893.
- Electrostatically-generated nanofibers of electronic polymersMacDiarmid A, Jones W, Norris I, Gao J, Johnson A, Pinto N, Hone J, Han B, Ko F, Okuzaki H, Llaguno M. Electrostatically-generated nanofibers of electronic polymers. Synthetic Metals 2001, 119: 27-30. DOI: 10.1016/s0379-6779(00)00597-x.
- Single carbon nanotube electronic devicesJohnson A, Lefebvre J, Radosavljevic M, Llaguno M, Lynch J. Single carbon nanotube electronic devices. AIP Conference Proceedings 2000, 544: 349-354. DOI: 10.1063/1.1342531.
- Electrical and thermal transport properties of magnetically aligned single wall carbon nanotube filmsHone J, Llaguno M, Nemes N, Johnson A, Fischer J, Walters D, Casavant M, Schmidt J, Smalley R. Electrical and thermal transport properties of magnetically aligned single wall carbon nanotube films. Applied Physics Letters 2000, 77: 666-668. DOI: 10.1063/1.127079.
- Single-wall carbon nanotube based devicesLefebvre J, Antonov R, Radosavljević M, Lynch J, Llaguno M, Johnson A. Single-wall carbon nanotube based devices. Carbon 2000, 38: 1745-1749. DOI: 10.1016/s0008-6223(00)00050-6.
- Thermal Properties of Single-Walled Carbon NanotubesHone J, Batlogg B, Benes Z, Llaguno M, Nemes N, Johnson A, Fischer J. Thermal Properties of Single-Walled Carbon Nanotubes. MRS Advances 2000, 633: a17.1. DOI: 10.1557/proc-633-a17.1.
- Single-wall carbon nanotube circuits assembled with an atomic force microscopeLefebvre J, Lynch J, Llaguno M, Radosavljevic M, Johnson A. Single-wall carbon nanotube circuits assembled with an atomic force microscope. Applied Physics Letters 1999, 75: 3014-3016. DOI: 10.1063/1.125218.