Morgan Levine, PhD

• Albert Higgins-Chen
• Barbara Burtness
• Heather Allore
• Henry S. Park
• Lajos Pusztai
• Mariya Rozenblit
• Melinda Irwin
• Xi Chen

Aging; Algorithms; Alzheimer Disease; Energy Intake; Longevity; Stem Cells; Genetic Variation; Cellular Senescence; DNA Methylation; Computational Biology; Gene Expression Profiling; Gene Regulatory Networks; Biostatistics; Clonal Evolution

• The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis.Fiorito G, Pedron S, Ochoa-Rosales C, McCrory C, Polidoro S, Zhang Y, Dugué PA, Ratliff S, Zhao WN, McKay GJ, Costa G, Solinas MG, Harris KM, Tumino R, Grioni S, Ricceri F, Panico S, Brenner H, Schwettmann L, Waldenberger M, Matias-Garcia PR, Peters A, Hodge A, Giles GG, Schmitz LL, Levine M, Smith JA, Liu Y, Kee F, Young IS, McGuinness B, McKnight AJ, van Meurs J, Voortman T, Kenny RA, Vineis P, Carmeli C. The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis. The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences 2022, 77: 1750-1759. PMID: 35172329, DOI: 10.1093/gerona/glac041.
• Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s diseaseThrush KL, Bennett DA, Gaiteri C, Horvath S, Dyck CHV, Higgins-Chen AT, Levine ME. Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s disease. Aging 2022, 14: 5641-5668. PMID: 35907208, PMCID: PMC9365556, DOI: 10.18632/aging.204196.
• A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal trackingHiggins-Chen AT, Thrush KL, Wang Y, Minteer CJ, Kuo PL, Wang M, Niimi P, Sturm G, Lin J, Moore AZ, Bandinelli S, Vinkers CH, Vermetten E, Rutten BPF, Geuze E, Okhuijsen-Pfeifer C, van der Horst MZ, Schreiter S, Gutwinski S, Luykx JJ, Picard M, Ferrucci L, Crimmins EM, Boks MP, Hägg S, Hu-Seliger TT, Levine ME. A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking. Nature Aging 2022, 2: 644-661. PMID: 36277076, PMCID: PMC9586209, DOI: 10.1038/s43587-022-00248-2.
• Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective studyCao X, Ma C, Zheng Z, He L, Hao M, Chen X, Crimmins EM, Gill TM, Levine ME, Liu Z. Contribution of life course circumstances to the acceleration of phenotypic and functional aging: A retrospective study. EClinicalMedicine 2022, 51: 101548. PMID: 35844770, PMCID: PMC9284373, DOI: 10.1016/j.eclinm.2022.101548.
• Life course traumas and cardiovascular disease—the mediating role of accelerated agingCao X, Zhang J, Ma C, Li X, Kuo C, Levine ME, Hu G, Allore H, Chen X, Wu X, Liu Z. Life course traumas and cardiovascular disease—the mediating role of accelerated aging. Annals Of The New York Academy Of Sciences 2022, 1515: 208-218. PMID: 35725988, PMCID: PMC10145586, DOI: 10.1111/nyas.14843.
• Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA VaccinationPang APS, Higgins-Chen AT, Comite F, Raica I, Arboleda C, Went H, Mendez T, Schotsaert M, Dwaraka V, Smith R, Levine ME, Ndhlovu LC, Corley MJ. Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination. Frontiers In Genetics 2022, 13: 819749. PMID: 35719387, PMCID: PMC9203887, DOI: 10.3389/fgene.2022.819749.
• Resilience integrates concepts in aging researchPromislow D, Anderson RM, Scheffer M, Crespi B, DeGregori J, Harris K, Horowitz BN, Levine ME, Riolo MA, Schneider DS, Spencer SL, Valenzano DR, Hochberg ME. Resilience integrates concepts in aging research. IScience 2022, 25: 104199. PMID: 35494229, PMCID: PMC9044173, DOI: 10.1016/j.isci.2022.104199.
• Evidence of accelerated epigenetic aging of breast tissues in patients with breast cancer is driven by CpGs associated with polycomb-related genesRozenblit M, Hofstatter E, Liu Z, O’Meara T, Storniolo AM, Dalela D, Singh V, Pusztai L, Levine M. Evidence of accelerated epigenetic aging of breast tissues in patients with breast cancer is driven by CpGs associated with polycomb-related genes. Clinical Epigenetics 2022, 14: 30. PMID: 35209953, PMCID: PMC8876160, DOI: 10.1186/s13148-022-01249-z.
• Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clockMinteer C, Morselli M, Meer M, Cao J, Higgins‐Chen A, Lang SM, Pellegrini M, Yan Q, Levine ME. Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock. Aging Cell 2022, 21: e13553. PMID: 35104377, PMCID: PMC8844113, DOI: 10.1111/acel.13553.
• Epigenetic aging of the demographically non-aging naked mole-ratKerepesi C, Meer MV, Ablaeva J, Amoroso VG, Lee SG, Zhang B, Gerashchenko MV, Trapp A, Yim SH, Lu AT, Levine ME, Seluanov A, Horvath S, Park TJ, Gorbunova V, Gladyshev VN. Epigenetic aging of the demographically non-aging naked mole-rat. Nature Communications 2022, 13: 355. PMID: 35039495, PMCID: PMC8763950, DOI: 10.1038/s41467-022-27959-9.
• Extending human healthspan and longevity: a symposium reportDeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. Annals Of The New York Academy Of Sciences 2021, 1507: 70-83. PMID: 34498278, PMCID: PMC10231756, DOI: 10.1111/nyas.14681.
• The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement StudySchmitz LL, Zhao W, Ratliff SM, Goodwin J, Miao J, Lu Q, Guo X, Taylor KD, Ding J, Liu Y, Levine M, Smith JA. The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study. Epigenetics 2021, 17: 589-611. PMID: 34227900, PMCID: PMC9235889, DOI: 10.1080/15592294.2021.1939479.
• Genetic associations for two biological age measures point to distinct aging phenotypesKuo C, Pilling LC, Liu Z, Atkins JL, Levine ME. Genetic associations for two biological age measures point to distinct aging phenotypes. Aging Cell 2021, 20: e13376. PMID: 34038024, PMCID: PMC8208797, DOI: 10.1111/acel.13376.
• Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal studyXiao C, Beitler JJ, Peng G, Levine ME, Conneely KN, Zhao H, Felger JC, Wommack EC, Chico CE, Jeon S, Higgins KA, Shin DM, Saba NF, Burtness BA, Bruner DW, Miller AH. Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study. Cancer 2021, 127: 3361-3371. PMID: 34027995, DOI: 10.1002/cncr.33641.
• A systematic review of biological, social and environmental factors associated with epigenetic clock accelerationOblak L, van der Zaag J, Higgins-Chen AT, Levine ME, Boks MP. A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration. Ageing Research Reviews 2021, 69: 101348. PMID: 33930583, DOI: 10.1016/j.arr.2021.101348.
• Association of Epigenetic Age Acceleration With Risk Factors, Survival, and Quality of Life in Patients With Head and Neck CancerXiao C, Miller AH, Peng G, Levine ME, Conneely KN, Zhao H, Eldridge RC, Wommack EC, Jeon S, Higgins KA, Shin DM, Saba NF, Smith AK, Burtness B, Park HS, Irwin ML, Ferrucci LM, Ulrich B, Qian DC, Beitler JJ, Bruner DW. Association of Epigenetic Age Acceleration With Risk Factors, Survival, and Quality of Life in Patients With Head and Neck Cancer. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: 157-167. PMID: 33882281, PMCID: PMC8802868, DOI: 10.1016/j.ijrobp.2021.04.002.
• Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank ParticipantsKuo CL, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Tignanelli C, Kuchel GA, Melzer D, Beckman KB, Levine ME. Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants. The Journals Of Gerontology Series A 2021, 76: e133-e141. PMID: 33684206, PMCID: PMC7989601, DOI: 10.1093/gerona/glab060.
• Aging biomarkers and the brainHiggins-Chen AT, Thrush KL, Levine ME. Aging biomarkers and the brain. Seminars In Cell And Developmental Biology 2021, 116: 180-193. PMID: 33509689, PMCID: PMC8292153, DOI: 10.1016/j.semcdb.2021.01.003.
• Associations of Age, Sex, Race/Ethnicity, and Education With 13 Epigenetic Clocks in a Nationally Representative U.S. Sample: The Health and Retirement StudyCrimmins EM, Thyagarajan B, Levine ME, Weir DR, Faul J. Associations of Age, Sex, Race/Ethnicity, and Education With 13 Epigenetic Clocks in a Nationally Representative U.S. Sample: The Health and Retirement Study. The Journals Of Gerontology Series A 2021, 76: 1117-1123. PMID: 33453106, PMCID: PMC8140049, DOI: 10.1093/gerona/glab016.
• Reprogramming to recover youthful epigenetic information and restore visionLu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature 2020, 588: 124-129. PMID: 33268865, PMCID: PMC7752134, DOI: 10.1038/s41586-020-2975-4.
• A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatinLevine M, McDevitt RA, Meer M, Perdue K, Di Francesco A, Meade T, Farrell C, Thrush K, Wang M, Dunn C, Pellegrini M, de Cabo R, Ferrucci L. A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin. ELife 2020, 9: e59201. PMID: 33179594, PMCID: PMC7661040, DOI: 10.7554/elife.59201.
• Underlying features of epigenetic aging clocks in vivo and in vitroLiu Z, Leung D, Thrush K, Zhao W, Ratliff S, Tanaka T, Schmitz LL, Smith JA, Ferrucci L, Levine ME. Underlying features of epigenetic aging clocks in vivo and in vitro. Aging Cell 2020, 19: e13229. PMID: 32930491, PMCID: PMC7576259, DOI: 10.1111/acel.13229.
• Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactionsHaghani A, Cacciottolo M, Doty KR, D'Agostino C, Thorwald M, Safi N, Levine ME, Sioutas C, Town TC, Forman HJ, Zhang H, Morgan TE, Finch CE. Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions. ELife 2020, 9: e54822. PMID: 32579111, PMCID: PMC7314548, DOI: 10.7554/elife.54822.
• Vasomotor Symptoms and Accelerated Epigenetic Aging in the Women’s Health Initiative (WHI)Thurston RC, Carroll JE, Levine M, Chang Y, Crandall C, Manson JE, Pal L, Hou L, Shadyab AH, Horvath S. Vasomotor Symptoms and Accelerated Epigenetic Aging in the Women’s Health Initiative (WHI). The Journal Of Clinical Endocrinology & Metabolism 2020, 105: 1221-1227. PMID: 32080740, PMCID: PMC7069347, DOI: 10.1210/clinem/dgaa081.
• Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine EffectsHiggins-Chen AT, Boks MP, Vinkers CH, Kahn RS, Levine ME. Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects. Biological Psychiatry 2020, 88: 224-235. PMID: 32199607, PMCID: PMC7368835, DOI: 10.1016/j.biopsych.2020.01.025.
• Assessment of Epigenetic Clocks as Biomarkers of Aging in Basic and Population ResearchLevine ME. Assessment of Epigenetic Clocks as Biomarkers of Aging in Basic and Population Research. The Journals Of Gerontology Series A 2020, 75: 463-465. PMID: 31995162, PMCID: PMC7328198, DOI: 10.1093/gerona/glaa021.
• Midlife Study of the Louisville Twins: Connecting Cognitive Development to Biological and Cognitive AgingBeam CR, Turkheimer E, Finkel D, Levine ME, Zandi E, Guterbock TM, Giangrande EJ, Ryan L, Pasquenza N, Davis DW. Midlife Study of the Louisville Twins: Connecting Cognitive Development to Biological and Cognitive Aging. Behavior Genetics 2019, 50: 73-83. PMID: 31820295, PMCID: PMC7033012, DOI: 10.1007/s10519-019-09983-6.
• Changing Disease Prevalence, Incidence, and Mortality Among Older Cohorts: The Health and Retirement StudyCrimmins EM, Zhang YS, Kim JK, Levine ME. Changing Disease Prevalence, Incidence, and Mortality Among Older Cohorts: The Health and Retirement Study. The Journals Of Gerontology Series A 2019, 74: s21-s26. PMID: 31724057, PMCID: PMC6853787, DOI: 10.1093/gerona/glz075.
• Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement StudyLiu Z, Chen X, Gill TM, Ma C, Crimmins EM, Levine ME. Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study. PLOS Medicine 2019, 16: e1002827. PMID: 31211779, PMCID: PMC6581243, DOI: 10.1371/journal.pmed.1002827.
• Correction: A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort studyLiu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M. Correction: A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study. PLOS Medicine 2019, 16: e1002760. PMID: 30802240, PMCID: PMC6388911, DOI: 10.1371/journal.pmed.1002760.
• The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. WomenLiu Z, Chen BH, Assimes TL, Ferrucci L, Horvath S, Levine ME. The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women. Psychoneuroendocrinology 2019, 104: 18-24. PMID: 30784901, PMCID: PMC6555423, DOI: 10.1016/j.psyneuen.2019.01.028.
• A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort studyLiu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M. A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study. PLOS Medicine 2018, 15: e1002718. PMID: 30596641, PMCID: PMC6312200, DOI: 10.1371/journal.pmed.1002718.
• Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in HumansYen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Scientific Reports 2018, 8: 14212. PMID: 30242290, PMCID: PMC6154958, DOI: 10.1038/s41598-018-32616-7.
• Time and the Metrics of AgingFerrucci L, Levine ME, Kuo PL, Simonsick EM. Time and the Metrics of Aging. Circulation Research 2018, 123: 740-744. PMID: 30355074, PMCID: PMC6205734, DOI: 10.1161/circresaha.118.312816.
• An epigenetic biomarker of aging for lifespan and healthspanLevine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. An epigenetic biomarker of aging for lifespan and healthspan. Aging 2018, 10: 573-591. PMID: 29676998, PMCID: PMC5940111, DOI: 10.18632/aging.101414.
• Predictors and implications of accelerated cognitive agingLevine ME, Harrati A, Crimmins EM. Predictors and implications of accelerated cognitive aging. Biodemography And Social Biology 2018, 64: 83-101. PMID: 31007841, PMCID: PMC6469682, DOI: 10.1080/19485565.2018.1552513.
• Is 60 the New 50? Examining Changes in Biological Age Over the Past Two DecadesLevine ME, Crimmins EM. Is 60 the New 50? Examining Changes in Biological Age Over the Past Two Decades. Demography 2018, 55: 387-402. PMID: 29511995, PMCID: PMC5897168, DOI: 10.1007/s13524-017-0644-5.
• GWAS of epigenetic aging rates in blood reveals a critical role for TERT.Lu AT, Xue L, Salfati EL, Chen BH, Ferrucci L, Levy D, Joehanes R, Murabito JM, Kiel DP, Tsai PC, Yet I, Bell JT, Mangino M, Tanaka T, McRae AF, Marioni RE, Visscher PM, Wray NR, Deary IJ, Levine ME, Quach A, Assimes T, Tsao PS, Absher D, Stewart JD, Li Y, Reiner AP, Hou L, Baccarelli AA, Whitsel EA, Aviv A, Cardona A, Day FR, Wareham NJ, Perry JRB, Ong KK, Raj K, Lunetta KL, Horvath S. GWAS of epigenetic aging rates in blood reveals a critical role for TERT. Nature Communications 2018, 9: 387. PMID: 29374233, PMCID: PMC5786029, DOI: 10.1038/s41467-017-02697-5.
• Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?Belsky DW, Moffitt TE, Cohen AA, Corcoran DL, Levine ME, Prinz JA, Schaefer J, Sugden K, Williams B, Poulton R, Caspi A. Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing? American Journal Of Epidemiology 2017, 187: 1220-1230. PMID: 29149257, PMCID: PMC6248475, DOI: 10.1093/aje/kwx346.
• A Weighted SNP Correlation Network Method for Estimating Polygenic Risk ScoresLevine ME, Langfelder P, Horvath S. A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores. 2017, 1613: 277-290. PMID: 28849564, PMCID: PMC5998804, DOI: 10.1007/978-1-4939-7027-8_10.
• Biological Age, Not Chronological Age, Is Associated with Late-Life DepressionBrown PJ, Wall MM, Chen C, Levine ME, Yaffe K, Roose SP, Rutherford BR. Biological Age, Not Chronological Age, Is Associated with Late-Life Depression. The Journals Of Gerontology Series A 2017, 73: 1370-1376. PMID: 28958059, PMCID: PMC6132120, DOI: 10.1093/gerona/glx162.
• Contemporaneous Social Environment and the Architecture of Late-Life Gene Expression ProfilesLevine ME, Crimmins EM, Weir DR, Cole SW. Contemporaneous Social Environment and the Architecture of Late-Life Gene Expression Profiles. American Journal Of Epidemiology 2017, 186: 503-509. PMID: 28911009, PMCID: PMC5860329, DOI: 10.1093/aje/kwx147.
• Genetic architecture of epigenetic and neuronal ageing rates in human brain regionsLu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S. Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nature Communications 2017, 8: 15353. PMID: 28516910, PMCID: PMC5454371, DOI: 10.1038/ncomms15353.
• Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo.Woodward NC, Levine MC, Haghani A, Shirmohammadi F, Saffari A, Sioutas C, Morgan TE, Finch CE. Toll-like receptor 4 in glial inflammatory responses to air pollution in vitro and in vivo. Journal Of Neuroinflammation 2017, 14: 84. PMID: 28410596, PMCID: PMC5391610, DOI: 10.1186/s12974-017-0858-x.
• Epigenetic clock analysis of diet, exercise, education, and lifestyle factorsQuach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, Ritz B, Bandinelli S, Neuhouser ML, Beasley JM, Snetselaar L, Wallace RB, Tsao PS, Absher D, Assimes TL, Stewart JD, Li Y, Hou L, Baccarelli AA, Whitsel EA, Horvath S. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging 2017, 9: 419-437. PMID: 28198702, PMCID: PMC5361673, DOI: 10.18632/aging.101168.
• DNA methylation-based measures of biological age: meta-analysis predicting time to deathChen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai PC, Roetker NS, Just AC, Demerath EW, Guan W, Bressler J, Fornage M, Studenski S, Vandiver AR, Moore AZ, Tanaka T, Kiel DP, Liang L, Vokonas P, Schwartz J, Lunetta KL, Murabito JM, Bandinelli S, Hernandez DG, Melzer D, Nalls M, Pilling LC, Price TR, Singleton AB, Gieger C, Holle R, Kretschmer A, Kronenberg F, Kunze S, Linseisen J, Meisinger C, Rathmann W, Waldenberger M, Visscher PM, Shah S, Wray NR, McRae AF, Franco OH, Hofman A, Uitterlinden AG, Absher D, Assimes T, Levine ME, Lu AT, Tsao PS, Hou L, Manson JE, Carty CL, LaCroix AZ, Reiner AP, Spector TD, Feinberg AP, Levy D, Baccarelli A, van Meurs J, Bell JT, Peters A, Deary IJ, Pankow JS, Ferrucci L, Horvath S. DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging 2016, 8: 1844-1859. PMID: 27690265, PMCID: PMC5076441, DOI: 10.18632/aging.101020.
• An epigenetic clock analysis of race/ethnicity, sex, and coronary heart diseaseHorvath S, Gurven M, Levine ME, Trumble BC, Kaplan H, Allayee H, Ritz BR, Chen B, Lu AT, Rickabaugh TM, Jamieson BD, Sun D, Li S, Chen W, Quintana-Murci L, Fagny M, Kobor MS, Tsao PS, Reiner AP, Edlefsen KL, Absher D, Assimes TL. An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome Biology 2016, 17: 171. PMID: 27511193, PMCID: PMC4980791, DOI: 10.1186/s13059-016-1030-0.
• Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women’s Health Initiative StudyCarroll JE, Irwin MR, Levine M, Seeman TE, Absher D, Assimes T, Horvath S. Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women’s Health Initiative Study. Biological Psychiatry 2016, 81: 136-144. PMID: 27702440, PMCID: PMC5536960, DOI: 10.1016/j.biopsych.2016.07.008.
• Menopause accelerates biological agingLevine ME, Lu AT, Chen BH, Hernandez DG, Singleton AB, Ferrucci L, Bandinelli S, Salfati E, Manson JE, Quach A, Kusters CD, Kuh D, Wong A, Teschendorff AE, Widschwendter M, Ritz BR, Absher D, Assimes TL, Horvath S. Menopause accelerates biological aging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 9327-9332. PMID: 27457926, PMCID: PMC4995944, DOI: 10.1073/pnas.1604558113.
• Education and Psychosocial Functioning Among Older Adults: 4-Year Change in Sense of Control and HopelessnessMitchell UA, Ailshire JA, Brown LL, Levine ME, Crimmins EM. Education and Psychosocial Functioning Among Older Adults: 4-Year Change in Sense of Control and Hopelessness. The Journals Of Gerontology Series B 2016, 73: gbw031. PMID: 27013537, PMCID: PMC6283311, DOI: 10.1093/geronb/gbw031.
• Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellumLu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S. Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nature Communications 2016, 7: 10561. PMID: 26830004, PMCID: PMC4740877, DOI: 10.1038/ncomms10561.
• Minimizing air pollution exposure: A practical policy to protect vulnerable older adults from death and disabilityWoodward N, Levine M. Minimizing air pollution exposure: A practical policy to protect vulnerable older adults from death and disability. Environmental Science & Policy 2016, 56: 49-55. PMID: 26640413, PMCID: PMC4667368, DOI: 10.1016/j.envsci.2015.10.018.
• Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioningLevine ME, Lu AT, Bennett DA, Horvath S. Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning. Aging 2015, 7: 1198-1211. PMID: 26684672, PMCID: PMC4712342, DOI: 10.18632/aging.100864.
• DNA methylation age of blood predicts future onset of lung cancer in the women's health initiativeLevine ME, Hosgood HD, Chen B, Absher D, Assimes T, Horvath S. DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative. Aging 2015, 7: 690-700. PMID: 26411804, PMCID: PMC4600626, DOI: 10.18632/aging.100809.
• A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in HumansLevine ME, Crimmins EM. A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans. The Journals Of Gerontology Series A 2015, 71: 703-712. PMID: 26355015, PMCID: PMC4888382, DOI: 10.1093/gerona/glv141.
• Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and OlderArpawong TE, Lee J, Phillips DF, Crimmins EM, Levine ME, Prescott CA. Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. Behavior Genetics 2015, 46: 72-88. PMID: 26330209, PMCID: PMC4720538, DOI: 10.1007/s10519-015-9740-8.
• Loneliness, eudaimonia, and the human conserved transcriptional response to adversityCole SW, Levine ME, Arevalo JM, Ma J, Weir DR, Crimmins EM. Loneliness, eudaimonia, and the human conserved transcriptional response to adversity. Psychoneuroendocrinology 2015, 62: 11-17. PMID: 26246388, PMCID: PMC4637182, DOI: 10.1016/j.psyneuen.2015.07.001.
• Quantification of biological aging in young adultsBelsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE. Quantification of biological aging in young adults. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: e4104-e4110. PMID: 26150497, PMCID: PMC4522793, DOI: 10.1073/pnas.1506264112.
• Early-Life Intelligence Predicts Midlife Biological AgeSchaefer JD, Caspi A, Belsky DW, Harrington H, Houts R, Israel S, Levine ME, Sugden K, Williams B, Poulton R, Moffitt TE. Early-Life Intelligence Predicts Midlife Biological Age. The Journals Of Gerontology Series B 2015, 71: 968-977. PMID: 26014827, PMCID: PMC5067943, DOI: 10.1093/geronb/gbv035.
• Childhood and later life stressors and increased inflammatory gene expression at older agesLevine ME, Cole SW, Weir DR, Crimmins EM. Childhood and later life stressors and increased inflammatory gene expression at older ages. Social Science & Medicine 2015, 130: 16-22. PMID: 25658624, PMCID: PMC4394113, DOI: 10.1016/j.socscimed.2015.01.030.
• A comparison of methods for assessing mortality riskLevine ME, Crimmins EM. A comparison of methods for assessing mortality risk. American Journal Of Human Biology 2014, 26: 768-776. PMID: 25088793, PMCID: PMC4286244, DOI: 10.1002/ajhb.22595.
• Evidence of accelerated aging among African Americans and its implications for mortalityLevine ME, Crimmins EM. Evidence of accelerated aging among African Americans and its implications for mortality. Social Science & Medicine 2014, 118: 27-32. PMID: 25086423, PMCID: PMC4197001, DOI: 10.1016/j.socscimed.2014.07.022.
• A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older AdultsLevine ME, Crimmins EM, Prescott CA, Phillips D, Arpawong TE, Lee J. A Polygenic Risk Score Associated with Measures of Depressive Symptoms Among Older Adults. Biodemography And Social Biology 2014, 60: 199-211. PMID: 25343367, PMCID: PMC4298361, DOI: 10.1080/19485565.2014.952705.
• Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older PopulationLevine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population. Cell Metabolism 2014, 19: 407-417. PMID: 24606898, PMCID: PMC3988204, DOI: 10.1016/j.cmet.2014.02.006.
• Not All Smokers Die Young: A Model for Hidden Heterogeneity within the Human PopulationLevine M, Crimmins E. Not All Smokers Die Young: A Model for Hidden Heterogeneity within the Human Population. PLOS ONE 2014, 9: e87403. PMID: 24520332, PMCID: PMC3919713, DOI: 10.1371/journal.pone.0087403.
• Response to Dr. Mitnitski’s and Dr. Rockwood’s Letter to the Editor: Biological Age RevisitedLevine ME. Response to Dr. Mitnitski’s and Dr. Rockwood’s Letter to the Editor: Biological Age Revisited. The Journals Of Gerontology Series A 2013, 69A: 297-298. PMID: 24115775, PMCID: PMC3976142, DOI: 10.1093/gerona/glt138.
• The role of physiological markers of health in the association between demographic factors and periodontal diseaseLevine ME, Kim JK, Crimmins EM. The role of physiological markers of health in the association between demographic factors and periodontal disease. Journal Of Periodontal Research 2012, 48: 367-372. PMID: 23231345, PMCID: PMC3609891, DOI: 10.1111/jre.12016.
• Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age?Levine ME. Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age? The Journals Of Gerontology Series A 2012, 68: 667-674. PMID: 23213031, PMCID: PMC3660119, DOI: 10.1093/gerona/gls233.
• The Impact of Insulin Resistance and Inflammation on the Association Between Sarcopenic Obesity and Physical FunctioningLevine ME, Crimmins EM. The Impact of Insulin Resistance and Inflammation on the Association Between Sarcopenic Obesity and Physical Functioning. Obesity 2012, 20: 2101-2106. PMID: 22310233, PMCID: PMC3527629, DOI: 10.1038/oby.2012.20.
• Sarcopenic Obesity and Cognitive Functioning: The Mediating Roles of Insulin Resistance and Inflammation?Levine ME, Crimmins EM. Sarcopenic Obesity and Cognitive Functioning: The Mediating Roles of Insulin Resistance and Inflammation? Current Gerontology And Geriatrics Research 2012, 2012: 826398. PMID: 22611388, PMCID: PMC3352243, DOI: 10.1155/2012/826398.
• Be WellKogan AC, Gonzalez J, Hart B, Halloran S, Thomason B, Levine M, Enguidanos S. Be Well. Journal Of Applied Gerontology 2012, 32: 889-901. PMID: 25474803, PMCID: PMC5923899, DOI: 10.1177/0733464812440043.
• Sex differences in the association between muscle quality, inflammatory markers, and cognitive decline.Canon ME, Crimmins EM. Sex differences in the association between muscle quality, inflammatory markers, and cognitive decline. The Journal Of Nutrition, Health & Aging 2011, 15: 695-8. PMID: 21968867, PMCID: PMC4315164, DOI: 10.1007/s12603-011-0340-x.