Qingji Xu, PhD
he/him/his
Postdoctoral Associate
Research & Publications
Biography
Locations
Research Summary
Qingji is passionate about unraveling the intricate mechanisms behind tumor-specific highly expressed molecules in cancer progression. His research interests span the discovery of novel biomarkers and the exploration of targeted therapies. Within the Yan Lab, he dedicates his efforts to understanding the role of histone methylation and retroelements in melanoma progression.
Research Interests
Immunotherapy; Melanoma; Biomarkers, Tumor; Gene Expression Regulation, Neoplastic; Molecular Targeted Therapy
Selected Publications
- CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway.Chen J, Xu Q, Liu D, Li X, Guo M, Chen X, Liao J, Lei R, Li W, Huang H, Saw PE, Song E, Yan X, Nie Y. CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway. Cancer Commun (Lond) 2023, 43: 1244-1266. PMID: 37856423, DOI: 10.1002/cac2.12495.
- Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146.Chen X, Yan H, Liu D, Xu Q, Duan H, Feng J, Yan X, Xie C. Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146. IScience 2021, 24: 102417. PMID: 33997697, DOI: 10.1016/j.isci.2021.102417.
- CD146, from a melanoma cell adhesion molecule to a signaling receptor.Wang Z, Xu Q, Zhang N, Du X, Xu G, Yan X. CD146, from a melanoma cell adhesion molecule to a signaling receptor. Signal Transduct Target Ther 2020, 5: 148. PMID: 32782280, DOI: 10.1038/s41392-020-00259-8.
- CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition.Ma Y, Zhang H, Xiong C, Liu Z, Xu Q, Feng J, Zhang J, Wang Z, Yan X. CD146 mediates an E-cadherin-to-N-cadherin switch during TGF-β signaling-induced epithelial-mesenchymal transition. Cancer Lett 2018, 430: 201-214. PMID: 29777784, DOI: 10.1016/j.canlet.2018.05.016.