Departments & Organizations
Abeel A. Mangi, MD, is an attending surgeon in the Section of Cardiac Surgery at Yale University, and is Surgical Director of the Program in Trans-Catheter Therapies and Surgical Director of the Center for Advanced Heart Failure, Mechanical Circulatory Support and Cardiac Transplantation at the Yale New Haven Heart & Vascular Institute.
Dr. Mangi is certified and re-certified by the American Board of Surgery, and is certified by the American Board of Thoracic Surgery. He is Associate Professor of Surgery at the Yale University School of Medicine.
He specializes in complex and re-operative cardiac surgery, trans-catheter valve repair and replacement, heart, heart-lung, and lung transplantation; ventricular assist devices, total artificial hearts, extracorporeal membrane oxygenation (ECMO); aortic and mitral valve repair and replacement, treatment of chronic pulmonary emboli, and ascending aortic and arch replacement.
Dr. Mangi has participated in over 2,500 heart operations, including almost 1,000 at Yale. His accomplishments include describing one of the first uses of VA-ECMO in an awake, ambulating patient as a successful bridge to lung transplantation; pioneering work in the area of trans-catheter valve replacement; recognizing the importance of surgical technique in avoiding LVAD failure; and investigating comparative cost-effectiveness of therapies for advanced heart failure.
Under his leadership, referrals to the heart failure program have increased substantially and come from every part of the region. Volume of the transplant and mechanical circulatory support programs has increased several-fold. Lengths of stay, morbidity and mortality are monitored in real time, and have steadily decreased. Quality has increased with outcomes better than the national averages in almost every category. Dr. Mangi is part of a team of 50 physicians and staff, and the program has an annual budget of almost $20 million and has generated a 23% contribution margin consistently.
Similarly, referrals to the valve program have increased substantially, with an 300% increase in TAVR volumes and a concomitant increase in surgical aortic valve volume of 25%. Lengths of stay, morbidity and mortality are monitored in real time, and have steadily decreased. Quality has increased with outcomes better than the national averages in almost every category. Dr. Mangi is a member of a team of 10 physicians and staff, and the program functions with an annual budget of almost $10 million and has generated a 40% contribution margin consistently.
Dr. Mangi has successfully implemented principles of robust optimization and dynamic work design into the Heart & Vascular Center at Yale New Haven Hospital, decreasing blood utilization in cardiac surgery from 78% to 22%; improving patient flow via operational efficiency resulting in 40-70% decreases in lengths of stay and a 30% decrease in cost per case; and via intelligent supply chain management.
Dr. Mangi earned his undergraduate and medical degrees from Brown University. He earned an MBA from the Sloan School of Management at the Massachusetts Institute of Technology. After completing his residency in general surgery at the Massachusetts General Hospital & Harvard Medical School, he was awarded a postdoctoral National Research Service Award fellowship from the National Institutes of Health, and won awards from the American Heart Association and the American College of Cardiology for ground-breaking stem cell research done at the Brigham & Women's Hospital and Harvard Medical School. He completed his fellowship in cardiac surgery at Columbia University and was then appointed as an Associate Staff Cardiac Surgeon at the Cleveland Clinic.
As principal or co-investigator in several dozen clinical trials and studies, Dr. Mangi has focused his research efforts on his specialty interests, including trans-catheter repair and replacement of diseased heart valves; the surgical treatment of ischemic heart failure, cellular therapy to treat advanced heart damage and expanded roles for left ventricular assist devices (LVADs). He is principal investigator on multiple clinical trials investigating catheter-based therapies for valvular heart disease and outcomes of patients supported on newer generation LVADs.
Dr. Mangi’s research investigates important questions regarding variables that influence clinical outcomes for therapies for end-stage cardiac patients – whether those with advanced heart valve disease or advanced heart failure. Large national databases such as the Interagency Registry for Mechanical Assisted Circulatory Support (INTERMACS), United Network for Organ Sharing (UNOS), Society for Thoracic Surgeons (STS) and the Nationwide Inpatient Sample (NIS) have been used to analyze cost and cost-effectiveness for such therapies and clinical prediction modeling. More recently, Dr. Mangi’s work has focused on dynamic work design in the health care delivery environment and optimal rational strategies to decrease costs of care.
Dr. Mangi has been invited to speak about his clinical experience and research findings at conferences and symposia worldwide. He is the author or co-author of numerous book chapters on subjects related to his specialty interests, including advances in cardiac intensive care, cardiac surgery, assist devices and treatment of heart failure. He has authored or co-authored over eighty published studies and abstracts in peer-reviewed publications, including Circulation, Nature Medicine, The Journal of Thoracic and Cardiovascular Surgery, and The Annals of Thoracic Surgery among others.
Dr. Mangi serves on multiple institutional, national and international committees, scientific advisory boards, and has been elected to membership and fellowship in the most esteemed organizations in his field including the International Society for Heart and Lung Transplantation, The American College of Cardiology, The Society for Thoracic Surgeons, The Society of University Surgeons, and The American College of Surgeons.
Education & Training
|MD||Brown University (1997)|
|BS||Brown University, Biology (1993)|
|Fellow||Columbia Presbyterian Medical Center|
|Senior Resident||Massachusetts General Hospital & Harvard Medical School|
|Research Fellow||Brigham & Women's Hospital & Harvard Medical School|
|Resident||Massachusetts General Hospital & Harvard Medical School|
|Intern||Massachusetts General Hospital & Harvard Medical School|
|Board Certification||AB of Surgery, Surgery, General (2005)|
|Board Certification||AB of Thoracic Surgery, Thoracic & Cardiac Surgery (2009)|