The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue


Brown Adipose Tissue

What is the purpose of this trial?

Specific Aim 1: To determine the effects of NET-PET imaging of BAT-associated regions in healthy adult humans. We will compare NET-PET labeling with FDG-PET labeling in healthy adults under conditions of room temperature and mild cold. The latter will be used to stimulate BAT activity.
We hypothesize that NET-PET and FDG-PET imaging of BAT regions will be highly correlated in healthy adults under mild cold stimulation conditions. We further hypothesize that NET-PET (unlike FDG-PET) will have the sensitivity to image BAT
distribution under room temperature conditions; however, with less intense labeling than under mild cold conditions.

Specific Aim 2: To determine the basic sex differences in NET-PET labeling of BAT under room temperature and mild cold temperature conditions. Studies with reboxetine indicate that NET may be less involved in cardiac norepinephrine turnover in women as compared to men17. FDG-PET has indicated the possibility of greater BAT mass and activity in women as compared to men 8.
We hypothesize that NET-PET imaging will detect gender differences in BAT for both room temperature and mild cold exposure.

Participation Guidelines

18 Years - 30 Years

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National Institute of Diabetes and Digestive & Kidney Diseases
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