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Krause Lab
Stem cells and cell fate in health and disease
The goal of the Krause Laboratory is to define how stem and progenitor cells balance and regulate fate decisions in health and disease. We study stem cells to improve strategies for repair and regeneration of the hematopoietic system as well as solid organs including the lung and parathyroids.
Situated in the Yale Stem Cell Center at the Yale School of Medicine, we develop cellular models of hematopoiesis using bone marrow derived stem and progenitor cells. Diane Krause serves as Medical Director of the Advanced Cell Therapy Laboratory; the lab is uniquely situated to translate insights from basic research into improved strategies for bone marrow and stem cell transplantation and novel treatments for leukemia and lymphoma. She is also Director of the Yale Cooperative Center of Excellence in Hematology (YCCEH)
Research Projects
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Featured Publications
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Blood | August 2025
RBM15-MKL1 fusion drives leukemia via m6A and Wnt pathways
This study investigates how the RBM15-MKL1 fusion protein drives acute megakaryoblastic leukemia by altering RNA methylation and activating the cancer-associated Wnt signaling pathway. The results are relevant for other forms of acute megakaryoblastic leukemia in which WNT is activated.
- Blood | October 2024
CDK9 Phosphorylates RUNX1 to Direct Blood Cell Fate
This study demonstrates that CDK9 phosphorylation of RUNX1 in human progenitors directs cell fate toward the megakaryocytic lineage and platelet production while reducing red blood cell formation.
Recent News
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- July 08, 2026
National Cancer Institute Grant Will Support Espinosa’s Leukemia Research
- July 08, 2025
Diane Krause, MD, PhD Honored With Highest Distinctions for Excellence in the Field - American Society of Hematology
- December 31, 2024
Accolades, Awards & Honors
- December 18, 2024
Yale research advances presented at American Society of Hematology annual meeting
Principal Investigator
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Diane Krause, MD, PhD
Anthony N. Brady Professor of Laboratory Medicine and Professor of Pathology