Skip to Main Content

Krause Lab

Stem cells and cell fate in health and disease

The goal of the Krause Laboratory is to define how stem and progenitor cells balance and regulate fate decisions in health and disease. We study stem cells to improve strategies for repair and regeneration of the hematopoietic system as well as solid organs including the lung and parathyroids.

Situated in the Yale Stem Cell Center at the Yale School of Medicine, we develop cellular models of hematopoiesis using bone marrow derived stem and progenitor cells. Diane Krause serves as Medical Director of the Advanced Cell Therapy Laboratory; the lab is uniquely situated to translate insights from basic research into improved strategies for bone marrow and stem cell transplantation and novel treatments for leukemia and lymphoma. She is also Director of the Yale Cooperative Center of Excellence in Hematology (YCCEH)

RBM15-MKL1 fusion drives leukemia via m6A and Wnt pathways

This study investigates how the RBM15-MKL1 fusion protein drives acute megakaryoblastic leukemia by altering RNA methylation and activating the cancer-associated Wnt signaling pathway. The results are relevant for other forms of acute megakaryoblastic leukemia in which WNT is activated.